Home / Clinical Resources / Differential Diagnosis

106 Differential Diagnoses.
Think Like a Clinician.

Every DDx is mapped to 5 learning modes — from rapid reference to interactive clinical reasoning. Across 17 specialties, build the pattern recognition and structured thinking that examiners test.

Explore all 106 differential diagnoses →
106
DDx
17
Specialties
5
Modes per DDx
Interactive
Reasoning

17 Specialties. 106 Presentations.

From the most common acute presentations to the high-yield rare diagnoses that separate good candidates from great ones.

Gastroenterology
Largest
20
Neurology
13
Cardiology
12
Endocrinology
10
Respiratory
8
Haematology
8
Nephrology & Urology
7
MSK & Rheumatology
4
ENT
4
Paediatrics
4
Surgery
4
Dermatology
3
Psychiatry
2
Emergency Medicine
2
Gynaecology
2
Ophthalmology
2
Infectious Disease
1

5 Modes. One Presentation.

Every differential diagnosis has 5 ways to study it — choose the mode that matches how you learn best.

📚
Mode 1

Deep Dive

Complete clinical analysis with pathophysiology, epidemiology, and full diagnostic workup for each differential.

Mode 2

Quick Reference

Rapid differential list with key distinguishing features — ideal for last-minute revision before exams.

🧠
Mode 3

Reason-It

Interactive clinical reasoning — work through the case step by step, narrowing your differential with each new clue.

🔀
Mode 4

Flowchart

Visual decision pathway from presentation to diagnosis — see how clinical features branch into different diagnoses.

🃏
Mode 5

DDx Cards

Flip cards with diagnosis on the front, key distinguishing features and discriminating investigations on the back.

Sample: Acute Chest Pain

See how MedNext presents a differential — likelihood-ranked, colour-coded, with distinguishing features at a glance.

A 42-year-old male presents to A&E with sudden-onset sharp chest pain, worse on inspiration. He is tachycardic and mildly hypoxic. No cardiac history. Smokes 10/day. Flew long-haul 48 hours ago.

Musculoskeletal

30%

ACS

35%

PE

20%

Pneumothorax

15%
Full case includes distinguishing features, key investigations, and 5 learning modes

Think Systematically. Every Time.

106 differential diagnoses across 17 specialties — each with 5 learning modes. Build the structured clinical thinking that separates good candidates from great ones.

Explore all 106 differential diagnoses →