Formulary
Sofosbuvir with velpatasvir: Indications, Dosing, Side Effects and Interactions
For sofosbuvir with velpatasvir Sofosbuvir is a nucleotide analogue inhibitor and velpatasvir is an HCV inhibitor; they reduce viral load by inhibiting...
MedNext Academy | 3 min read
Sofosbuvir with velpatasvir: Indications, Dosing, Side Effects and Interactions
For sofosbuvir with velpatasvir Sofosbuvir is a nucleotide analogue inhibitor and velpatasvir is an HCV inhibitor; they reduce viral load by inhibiting...
Drug action
For sofosbuvir with velpatasvir Sofosbuvir is a nucleotide analogue inhibitor and velpatasvir is an HCV inhibitor; they reduce viral load by inhibiting hepatitis C virus RNA replication.
Indications and dose
**Chronic hepatitis C infection (under expert supervision)**
- **Adult** (By Mouth): 400/100 mg once daily for 12 weeks (may extend to 24 weeks in some circumstances-consult product literature).
**Chronic hepatitis C infection (under expert supervision) for sofosbuvir with velpatasvir**
- **Child 3-17 years (body-weight up to 17 kg)** (By mouth using granules): 150/37.5 mg once daily for 12 weeks.
- **Child 3-17 years (body-weight 17-29 kg)** (By mouth): 200/50 mg once daily for 12 weeks.
- **Child 3-17 years (body-weight 30 kg and above)** (By mouth): 400/100 mg once daily for 12 weeks.
Side effects
For sofosbuvir with velpatasvir Common or very common Rash Uncommon Angioedema Frequency not known Fatigue; headache; hepatitis B reactivation; nausea; Stevens-Johnson syndrome
Medicinal forms
Tablet,Granules
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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