Formulary
Progesterone: Indications, Dosing, Side Effects and Interactions
Progesterone clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Progesterone: Indications, Dosing, Side Effects and Interactions
Progesterone clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Supplementation of luteal phase during assisted reproductive technology (ART) treatment in women**
- **Adult** (By Subcutaneous Injection, Or By Intramuscular Injection): for whom vaginal preparations are inappropriate 25 mg once daily from day of oocyte retrieval up to week 12 of pregnancy.
**Progestogenic opposition of oestrogen HRT**
- **Adult** (By Mouth): 200 mg once daily on days 15-26 of each 28-day oestrogen HRT cycle, alternatively 100 mg once daily on days 1-25 of each 28-day oestrogen HRT cycle.
Cautions
Conditions that may worsen with fluid retention; diabetes (progestogens can decrease glucose tolerance-monitor patient closely); history of depression; migraine; risk factors for thromboembolism
Contraindications
Acute porphyrias ; breast cancer; genital cancer; history during pregnancy of idiopathic jaundice; history during pregnancy of pemphigoid gestationis; history during pregnancy of severe pruritus; history of thromboembolism; missed miscarriage; thrombophlebitis; undiagnosed vaginal bleeding
Side effects
Common or very common With oral use Headache; menstrual cycle irregularities With vaginal use Breast pain; drowsiness; gastrointestinal discomfort Uncommon With oral use Breast pain; constipation; diarrhoea; dizziness; drowsiness; jaundice cholestatic; skin reactions; vomiting Rare or very rare With oral use Depression; nausea Frequency not known With intramuscular use Alopecia; breast changes; cervical abnormalities; depression; drowsiness; fever; hirsutism; insomnia; jaundice cholestatic; menstrual cycle irregularities; nausea; oedema; protein catabolism; skin reactions; weight increased With rectal use Diarrhoea; flatulence With vaginal use Leakage of the pessary base; menstrual cycle irregularities; vulvovaginal pain
Interactions
**Severe interactions:**
- Effect of HRT with oestrogens on other medicinal products Hormone contraceptives containing oestrogens have been shown to significantly decrease plasma concentrations of lamotrigine when...
- Pharmacodynamic interactions During clinical trials with the HCV combination drug regimen ombitasvir/paritaprevir/ritonavir and dasabuvir with or without ribavirin, ALT elevations greater than 5...
**Other interactions (8):**
- No drug-drug interaction studies have been conducted with Bijuve The drug-drug interactions of estradiol and progesterone have been extensively studied and are well established.
- Both estrogens and progesterone are metabolized via cytochrome P450 Effects of other medicinal products on Bijuve The metabolism of estrogens and progestogens may be increased by concomitant use of...
- Herbal preparations containing St John's Wort (Hypericum perforatum) may induce the metabolism of oestrogens and progestogens.
- Ritonavir and nelfinavir, although known as strong inhibitors, by contrast exhibit inducing properties when used concomitantly with steroid hormones.
- Ketoconazole and other inhibitors of CYP450-3A4 may increase bioavailability of progesterone.
- Such interactions may increase the incidence of adverse effects such as nausea, breast tenderness, headaches associated with progesterone Effects of Bijuve on other medicinal products Progesterone...
Pregnancy
Not known to be harmful.
Breast feeding
Avoid-present in milk.
Hepatic impairment
Manufacturer advises caution; avoid in severe impairment. For Utrogestan oral capsules , manufacturer advises avoid in acute or active liver disease. For Crinone vaginal gel , manufacturer advises caution in severe impairment.
Renal impairment
Caution (risk of fluid retention; no information available). M
Medicinal forms
Solution,Capsule,Solution,Pessary,Capsule,Gel
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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