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Estradiol with progesterone: Indications, Dosing, Side Effects and Interactions
Estradiol with progesterone clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Estradiol with progesterone: Indications, Dosing, Side Effects and Interactions
Estradiol with progesterone clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Menopausal symptoms in women with a uterus whose last menstrual period occurred over 12 months previously**
- **Adult** (By Mouth): 1 capsule daily continuously, dose to be taken in the evening with food, if changing from continuous sequential or cyclical HRT, start treatment the day after finishing the 28-day cycle. Treatment may start immediately after surgical menopause or if changing from another continuous combined HRT.
Side effects
For estradiol with progesterone Common or very common Alopecia; breast abnormalities; dizziness; fatigue; gastrointestinal discomfort; haemorrhage; headaches; nausea; pain; pelvic pain; skin reactions; uterine disorders; vulvovaginal disorders; weight changes Uncommon Altered smell sensation; anaemia; anxiety; arthralgia; cervical abnormalities; chills; concentration impaired; constipation; depression; diarrhoea; drowsiness; dry mouth; flatulence; fluid retention; hirsutism; hot flush; hyperlipidaemia; hyperphagia; hypertension; hyperuricaemia; increased risk of infection; leiomyoma; libido increased; memory impairment; metrorrhagia; mood altered; muscle spasms; neoplasms; oral discomfort; pancreatitis acute; paraesthesia; postmenopausal haemorrhage; sleep disorders; taste altered; telangiectasia; thrombophlebitis; vertigo; visual impairment; vomiting
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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