Formulary
Palonosetron: Indications, Dosing, Side Effects and Interactions
Palonosetron is a specific 5HT 3 -receptor antagonist which blocks 5HT 3 receptors in the gastro-intestinal tract and in the CNS.
MedNext Academy | 3 min read
Palonosetron: Indications, Dosing, Side Effects and Interactions
Palonosetron is a specific 5HT 3 -receptor antagonist which blocks 5HT 3 receptors in the gastro-intestinal tract and in the CNS.
Drug action
Palonosetron is a specific 5HT 3 -receptor antagonist which blocks 5HT 3 receptors in the gastro-intestinal tract and in the CNS.
Indications and dose
**Severely emetogenic chemotherapy**
- **Adult** (By Intravenous Injection): 250 micrograms for 1 dose, dose to be administered over 30 seconds, 30 minutes before treatment.
Cautions
History of constipation; intestinal obstruction; susceptibility to QT-interval prolongation (including electrolyte disturbances)
Side effects
General side-effects: Common or very common Constipation; headache Specific side-effects: Common or very common With intravenous use Diarrhoea; dizziness; electrolyte imbalance; metabolic disorder Uncommon With intravenous use Amblyopia; anxiety; appetite decreased; arrhythmias; arthralgia; asthenia; drowsiness; dry mouth; dyspepsia; euphoric mood; eye irritation; feeling hot; fever; flatulence; glycosuria; hiccups; hyperbilirubinaemia; hyperglycaemia; hypertension; hypotension; influenza like illness; motion sickness; myocardial ischaemia; paraesthesia; peripheral neuropathy; QT interval prolongation; skin reactions; sleep disorders; tinnitus; urinary retention; vasodilation; vein discolouration With oral use Atrioventricular block; dyspnoea; eye swelling; insomnia; myalgia Rare or very rare With intravenous use Shock
Pregnancy
Avoid-no information available.
Breast feeding
Avoid-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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