Formulary
Macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride: Indications, Dosing, Side Effects and Interactions
Macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride: Indications, Dosing, Side Effects and Interactions
Macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Bowel cleansing [before any procedure requiring a clean bowel]**
- **Adult** (By Mouth): 500 mL daily for 2 doses; first dose of reconstituted solution taken on the evening before procedure and the second dose on the morning of procedure, alternatively 1 litre daily in 2 divided doses, reconstituted solution to be taken either on the evening before the procedure, or in the morning of the procedure-separate doses by at least 1 hour, treatment should be completed at least 1 hour before clinical procedures conducted without general anaesthesia, and at least 2 hours before clinical procedures conducted under general anaesthesia.
Cautions
For macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride Debilitated patients; dehydration (correct before administration); impaired consciousness; impaired gag reflex or possibility of regurgitation or aspiration; moderate-to-severe cardiac impairment; patients at risk of arrhythmia (including those with thyroid disease or electrolyte imbalance); severe acute inflammatory bowel disease
Contraindications
For macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride Disorders of gastric emptying; G6PD deficiency; gastro-intestinal obstruction; gastro-intestinal perforation; ileus; toxic megacolon
Side effects
For macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride Common or very common Chills; dehydration; dizziness; fever; gastrointestinal discomfort; headaches; hunger; malaise; nausea; sleep disorder; thirst; vomiting Uncommon Arrhythmias; asthenia; drowsiness; dry mouth; dry throat; dysphagia; electrolyte imbalance; hot flush; pain; palpitations; temperature sensation altered Frequency not known Flatulence; hyponatraemic seizure Side-effects, further information Abdominal pain is usually transient and can be reduced by taking preparation more slowly.
Pregnancy
For macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride Manufacturer advises use only if essential-no or limited information available.
Breast feeding
For macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride Manufacturer advises use only if essential-no information available.
Renal impairment
For macrogol 3350 with anhydrous sodium sulfate, ascorbic acid, potassium chloride, sodium ascorbate and sodium chloride Manufacturer advises caution if creatinine clearance less than 30 mL/minute. See Prescribing in renal impairment .
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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