Formulary
Ledipasvir with sofosbuvir: Indications, Dosing, Side Effects and Interactions
For ledipasvir with sofosbuvir Sofosbuvir is a nucleotide analogue inhibitor and ledipasvir is an HCV inhibitor; they reduce viral load by inhibiting...
MedNext Academy | 3 min read
Ledipasvir with sofosbuvir: Indications, Dosing, Side Effects and Interactions
For ledipasvir with sofosbuvir Sofosbuvir is a nucleotide analogue inhibitor and ledipasvir is an HCV inhibitor; they reduce viral load by inhibiting...
Drug action
For ledipasvir with sofosbuvir Sofosbuvir is a nucleotide analogue inhibitor and ledipasvir is an HCV inhibitor; they reduce viral load by inhibiting hepatitis C virus RNA replication.
Indications and dose
**Chronic hepatitis C infection (under expert supervision)**
- **Adult** (By Mouth): 90/400 mg once daily, for treatment duration-consult product literature.
**Chronic hepatitis C infection (under expert supervision) for ledipasvir with sofosbuvir**
- **Child 3-17 years (body-weight up to 17 kg)** (By mouth using granules): 33.75/150 mg once daily, for treatment duration-consult product literature.
- **Child 3-17 years (body-weight 17-34 kg)** (By mouth): 45/200 mg once daily, for treatment duration-consult product literature.
- **Child 3-17 years (body-weight 35 kg and above)** (By mouth): 90/400 mg once daily, for treatment duration-consult product literature.
Cautions
For ledipasvir with sofosbuvir Retreatment following treatment failure-efficacy not established
Side effects
For ledipasvir with sofosbuvir Common or very common Fatigue; headache; rash Frequency not known Angioedema; hepatitis B reactivation; Stevens-Johnson syndrome
Medicinal forms
Tablet,Granules
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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