Formulary
Doxylamine with pyridoxine: Indications, Dosing, Side Effects and Interactions
For doxylamine with pyridoxine Doxylamine is a first-generation antihistamine which selectively binds H 1 receptors in the brain; pyridoxine (vitamin B 6 ) is...
MedNext Academy | 3 min read
Doxylamine with pyridoxine: Indications, Dosing, Side Effects and Interactions
For doxylamine with pyridoxine Doxylamine is a first-generation antihistamine which selectively binds H 1 receptors in the brain; pyridoxine (vitamin B 6 ) is...
Drug action
For doxylamine with pyridoxine Doxylamine is a first-generation antihistamine which selectively binds H 1 receptors in the brain; pyridoxine (vitamin B 6 ) is a water-soluble vitamin.
Indications and dose
**Nausea and vomiting in pregnancy**
- **Adult** (By Mouth): 20/20 mg once daily for 2 days, to be taken at bedtime; increased if necessary to 10/10 mg, to be taken in the morning and 20/20 mg, to be taken at bedtime; increased if necessary to 10/10 mg, to be taken in the morning, 10/10 mg, to be taken mid-afternoon and 20/20 mg, to be taken at bedtime; maximum 40/40 mg per day.
Cautions
For doxylamine with pyridoxine Asthma; bladder neck obstruction; increased intra-ocular pressure; narrow angle glaucoma; pyloroduodenal obstruction; stenosing peptic ulcer
Side effects
For doxylamine with pyridoxine Common or very common Dizziness; drowsiness; dry mouth; fatigue Frequency not known Akathisia; anxiety; chest discomfort; constipation; diarrhoea; disorientation; dyspnoea; gastrointestinal discomfort; headaches; hyperhidrosis; irritability; malaise; palpitations; paraesthesia; skin reactions; sleep disorders; tachycardia; urinary disorders; vertigo; vision disorders
Pregnancy
Nausea and vomiting in pregnancy for doxylamine with pyridoxine By mouth Adult 20/20 mg once daily for 2 days, to be taken at bedtime; increased if necessary to 10/10 mg, to be taken in the morning and 20/20 mg, to be taken at bedtime; increased if necessary to 10/10 mg, to be taken in the morning, 10/10 mg, to be taken mid-afternoon and 20/20 mg, to be taken at bedtime; maximum 40/40 mg per day.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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