Clinical tools
Drug Interactions Checker
Review potential medicine interactions inside the MedNext formulary workflow.
Explore MedNextDrug Interactions Checker
Review potential medicine interactions inside the MedNext formulary workflow.
The checker is a reference aid. Confirm severity, patient factors, monitoring and management against current prescribing guidance before changing treatment.
Classic dangerous interactions
A taste of what is inside. For each pairing the checker explains the mechanism and the practical action. These are illustrative examples; always confirm severity and management against current prescribing guidance for your patient.
Warfarin plus an NSAID. Mechanism: NSAIDs add antiplatelet effect and cause gastric mucosal injury, and some displace warfarin from protein binding, so bleeding risk rises sharply, especially gastrointestinal bleeding. What to do: avoid the combination where possible, prefer paracetamol for analgesia, and if an NSAID is unavoidable use gastric protection and monitor the INR closely.
A statin plus a macrolide. Mechanism: macrolides such as clarithromycin and erythromycin inhibit CYP3A4, which raises the plasma level of CYP3A4-metabolised statins such as simvastatin and atorvastatin, increasing the risk of myopathy and rhabdomyolysis. What to do: withhold or reduce the statin during the antibiotic course, choose a macrolide or statin with less interaction, and counsel the patient to report muscle pain or dark urine.
An MAOI plus an SSRI. Mechanism: combined excess serotonergic activity can precipitate serotonin syndrome, with agitation, autonomic instability, hyperthermia, clonus and rigidity. What to do: do not co-prescribe; observe the required washout period when switching between agents, per current guidance, and treat suspected serotonin syndrome as an emergency by stopping the drugs and seeking urgent help.
The checker screens across the full formulary of 1,800+ drugs. This is a taste of what is inside; the full interactive tool is in the MedNext app.
Continue from Drug Interactions Checker
Explore clinician-written learning resources, structured revision and practice across the MedNext platform.
See plans