Formulary
Zilucoplan: Indications, Dosing, Side Effects and Interactions
Zilucoplan is a synthetic macrocyclic peptide that inhibits complement activation at the C5 protein, thereby reducing complement-mediated cell damage.
MedNext Academy | 3 min read
Zilucoplan: Indications, Dosing, Side Effects and Interactions
Zilucoplan is a synthetic macrocyclic peptide that inhibits complement activation at the C5 protein, thereby reducing complement-mediated cell damage.
Drug action
Zilucoplan is a synthetic macrocyclic peptide that inhibits complement activation at the C5 protein, thereby reducing complement-mediated cell damage.
Indications and dose
**Myasthenia gravis (under expert supervision)**
- **Adult** (By Subcutaneous Injection): (body-weight 77 kg and above) 32.4 mg once daily.
Cautions
Neisseria infection Cautions, further information Meningococcal infection Vaccinate against Neisseria meningitidis at least 2 weeks before treatment (vaccines against serotypes A, C, Y, W135, and B where available, are recommended); revaccinate according to current medical guidelines. Patients receiving zilucoplan less than 2 weeks after receiving meningococcal vaccine must be given prophylactic antibiotics until 2 weeks after vaccination. Other immunisations should also be up to date. M
Contraindications
Patients unvaccinated against Neisseria meningitidis ; unresolved Neisseria meningitidis infection
Side effects
Common or very common Diarrhoea; increased risk of infection; morphoea
Pregnancy
Use only if potential benefit outweighs risk (no information available). M
Breast feeding
Specialist sources indicate probably compatible (no information available). Degradation into small peptides and amino acids via catabolic pathways in the maternal circulation and infant gastro-intestinal tract suggests unlikely to be absorbed by, or adversely affect the breast-fed infant.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Zilucoplan in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

