Formulary
Vinorelbine [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Vinorelbine [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Vinorelbine [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Vinorelbine [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Breast cancer,Non-small cell lung cancer**
- **Adult** (By Mouth, Or By Intravenous Injection, Or By Intravenous Infusion): Specialist drug - access specialist resources for dosing information.
Contraindications
For vinorelbine [Specialist drug] General contra-indications: Concurrent radiotherapy if treating the liver Specific contra-indications: With oral use Long-term oxygen therapy; previous significant surgical resection of small bowel; previous significant surgical resection of stomach Contra-indications, further information Intrathecal injection contra-indicated .
Side effects
For vinorelbine [Specialist drug] General side-effects: Common or very common Alopecia; anaemia; appetite decreased; arthralgia; bone marrow depression (dose-limiting); constipation; diarrhoea; dyspnoea; fever; hypertension; hypotension; increased risk of infection; leucopenia; myalgia; nausea; neutropenia (dose-limiting); pain; reflexes absent; stomatitis; thrombocytopenia; vomiting Uncommon Bronchospasm; flushing; peripheral coldness; sepsis Rare or very rare Circulatory collapse; hyponatraemia; interstitial lung disease; myocardial infarction; pancreatitis Frequency not known SIADH Specific side-effects: Common or very common With intravenous use Asthenia; cancer pain; chest pain; muscle weakness in legs; nervous system disorder; vein discolouration With oral use Abdominal pain; chills; cough; dizziness; dysphagia; dysuria; fatigue; gastrointestinal disorders; headache; insomnia; liver disorder; neuromuscular disorders; sensory disorder; skin eruption; taste altered; urogenital disorder; vision disorder; weight changes Uncommon With intravenous use Paraesthesia With oral use Ataxia Rare or very rare With intravenous use Arrhythmias; ischaemic heart disease; necrosis; palpitations; paralytic ileus; skin reactions Frequency not known With intravenous use Febrile neutropenia With oral use Gastrointestinal haemorrhage; hypersensitivity Side-effects, further information Bronchospasm Severe bronchospasm following administration of the vinca alkaloids is more common when used in combination with mitomycin-C. Neurotoxicity Neurotoxicity reported in clinical trials, most commonly as constipation, paresthesia, hypersthesia, and hyporeflexia.
Medicinal forms
Capsule,Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Vinorelbine [Specialist drug] in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

