Formulary
Vincristine sulfate [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Vincristine sulfate [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Vincristine sulfate [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Vincristine sulfate [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Leukaemias,Lymphomas,Solid tumours [including breast cancer and lung cancer]**
- **Adult** (By Intravenous Injection, Or By Intravenous Infusion): Specialist drug - access specialist resources for dosing information.
Contraindications
For vincristine sulfate [Specialist drug] Contra-indications, further information Intrathecal injection contra-indicated .
Side effects
For vincristine sulfate [Specialist drug] Rare or very rare Hypersensitivity; rash; SIADH Frequency not known Abdominal cramps; adrenal disorder; alopecia; anaemia; appetite decreased; azotaemia; bladder atony; bronchospasm; connective tissue disorders; constipation; coronary artery disease; dehydration; diarrhoea; dizziness; dyspnoea; eighth cranial nerve damage; eye disorders; fever; gait abnormalities; gastrointestinal disorders; haemolytic anaemia; headache; hearing impairment; hypertension; hyponatraemia; hypotension; infection; leucopenia; movement disorders; muscle atrophy; myalgia; myocardial infarction; nausea; neuromuscular effects (dose-limiting); neutropenia; oedema; oral ulceration; pain; paralysis; paresis; reflexes absent; renal disorder; secondary malignancy; sensation abnormal; sepsis; throat pain; thrombocytopenia; urinary disorders; vertigo; vestibular damage; vision loss; vomiting; weight decreased Side-effects, further information Bronchospasm Severe bronchospasm following administration is more common when used in combination with mitomycin-C. Neurotoxicity Sensory and motor neuropathies are common and are cumulative. Manufacturer advises monitoring patients for symptoms of neuropathy, such as hypoesthesia, hyperesthesia, paresthesia, hyporeflexia, areflexia, neuralgia, jaw pain, decreased vibratory sense, cranial neuropathy, ileus, burning sensation, arthralgia, myalgia, muscle spasm, or weakness, both before and during treatment-requires dose reduction, treatment interruption or treatment discontinuation, depending on severity. Motor weakness can also occur and dose reduction or discontinuation of therapy may be appropriate if motor weakness increases. Recovery from neurotoxic effects is usually slow but complete.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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