Formulary
Vibegron: Indications, Dosing, Side Effects and Interactions
Vibegron, a selective beta 3 -adrenoceptor agonist, relaxes the detrusor muscle during filling, thereby increasing bladder capacity.
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Vibegron: Indications, Dosing, Side Effects and Interactions
Vibegron, a selective beta 3 -adrenoceptor agonist, relaxes the detrusor muscle during filling, thereby increasing bladder capacity.
Drug action
Vibegron, a selective beta 3 -adrenoceptor agonist, relaxes the detrusor muscle during filling, thereby increasing bladder capacity.
Indications and dose
**Symptomatic treatment of overactive bladder syndrome**
- **Adult** (By Mouth): 75 mg once daily.
Side effects
Common or very common Constipation; diarrhoea; headache; nausea; urinary tract infection Uncommon Hot flush; skin reactions; urinary disorders
Interactions
**Other interactions (11):**
- Vibegron is a substrate for cytochrome P450 (CYP) 3A4, multiple UGT enzymes and the efflux transporter P-glycoprotein (P-gp).
- Medicinal products affecting the exposure of vibegron CYP3A4/P-gp inhibitors Vibegron exposure (AUC) was increased 2.1--and 1.6-fold in the presence of the strong and moderate inhibitor of...
- No dose-adjustment is needed when vibegron is combined with strong and moderate inhibitors of CYP3A and/or P-gp.
- CYP3A4/P-gp inducers Vibegron AUC was not affected by repeat-dose administration of rifampicin, a strong inducer of CYP3A/P-gp, in healthy volunteers, while vibegron C max was 86% higher.
- No dose adjustment is needed for vibegron when administered with CYP3A or P-gp inducers.
- Effect of vibegron on other medicinal products.
Pregnancy
Avoid (toxicity in animal studies). M
Breast feeding
Avoid (present in milk in animal studies). M
Hepatic impairment
Avoid in severe impairment (no information available). M
Renal impairment
Avoid if creatinine clearance less than 15 mL/minute (no information available). M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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