Formulary
Velaglucerase alfa: Indications, Dosing, Side Effects and Interactions
Velaglucerase alfa is an enzyme produced by recombinant DNA technology that is administered as enzyme replacement therapy for the treatment of type I...
MedNext Academy | 3 min read
Velaglucerase alfa: Indications, Dosing, Side Effects and Interactions
Velaglucerase alfa is an enzyme produced by recombinant DNA technology that is administered as enzyme replacement therapy for the treatment of type I...
Drug action
Velaglucerase alfa is an enzyme produced by recombinant DNA technology that is administered as enzyme replacement therapy for the treatment of type I Gaucher's disease.
Indications and dose
**Type I Gaucher's disease (specialist use only)**
- **Adult** (By Intravenous Infusion): Initially 60 units/kg every 2 weeks; adjusted according to response to 15-60 units/kg every 2 weeks.
**Type I Gaucher's disease (specialist use only) for velaglucerase alfa**
- **Child 4-17 years** (By intravenous infusion): Initially 60 units/kg every 2 weeks; adjusted according to response to 15-60 units/kg every 2 weeks.
Side effects
Common or very common Arthralgia; asthenia; chest discomfort; dizziness; dyspnoea; fever; flushing; gastrointestinal discomfort; headache; hypersensitivity; hypertension; hypotension; infusion related reaction; nausea; pain; skin reactions; tachycardia Side-effects, further information Infusion-related reactions are very common; manage by slowing the infusion rate, or interrupting the infusion, or minimise by pre-treatment with an antihistamine, antipyretic, or corticosteroid-consult product literature.
Pregnancy
Manufacturer advises use with caution-limited information available.
Breast feeding
Manufacturer advises use with caution-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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