Formulary
Typhoid vaccine (inactivated): Indications, Dosing, Side Effects and Interactions
For typhoid vaccine (inactivated) The inactivated typhoid vaccine is an injectable polysaccharide vaccine that protects against typhoid fever caused by...
MedNext Academy | 3 min read
Typhoid vaccine (inactivated): Indications, Dosing, Side Effects and Interactions
For typhoid vaccine (inactivated) The inactivated typhoid vaccine is an injectable polysaccharide vaccine that protects against typhoid fever caused by...
Drug action
For typhoid vaccine (inactivated) The inactivated typhoid vaccine is an injectable polysaccharide vaccine that protects against typhoid fever caused by Salmonella typhi infection. For information on the live vaccine, see typhoid vaccine (live) .
Indications and dose
**Immunisation against typhoid fever [in children at high risk of typhoid fever]**
- **Child** (By Intramuscular Injection): 12-23 months 0.5 mL for 1 dose, dose should be given at least 2 weeks before potential exposure to typhoid infection, response may be suboptimal.
**Immunisation against typhoid fever**
- **Child** (By Intramuscular Injection): 2-17 years 0.5 mL for 1 dose, dose should be given at least 2 weeks before potential exposure to typhoid infection.
- **Adult** (By Intramuscular Injection): 0.5 mL for 1 dose, dose should be given at least 2 weeks before potential exposure to typhoid infection.
**Booster**
- **Child** (By Intramuscular Injection): 2-17 years 0.5 mL for 1 dose every 3 years.
- **Adult** (By Intramuscular Injection): 0.5 mL for 1 dose every 3 years.
**Immunisation against typhoid fever [in children at high risk of typhoid fever] for typhoid vaccine (inactivated)**
- **Child 12-23 months** (By intramuscular injection): 0.5 mL for 1 dose, dose should be given at least 2 weeks before potential exposure to typhoid infection, response may be suboptimal.
**Immunisation against typhoid fever for typhoid vaccine (inactivated)**
- **Child 2-17 years** (By intramuscular injection): 0.5 mL for 1 dose, dose should be given at least 2 weeks before potential exposure to typhoid infection.
**Booster for typhoid vaccine (inactivated)**
- **Child 2-17 years** (By intramuscular injection): 0.5 mL for 1 dose every 3 years.
Cautions
For all vaccines, general Acute illness; minor illnesses Cautions, further information Illness UKHSA advises vaccination may be postponed if the individual is suffering from an acute illness; however, it is not necessary to postpone immunisation in patients with minor illnesses without fever or systemic upset. Predisposition to neurological problems UKHSA advises: when there is a personal or family history of febrile convulsions, there is an increased risk of these occurring during fever from any cause including immunisation, but this is not a contra-indication to immunisation. In children who have had a seizure associated with fever without neurological deterioration, immunisation is recommended ; advice on the management of fever should be given before immunisation. When a child has had a convulsion not associated with fever, and the neurological condition is not deteriorating, immunisation is recommended ; children with stable neurological disorders (e.g. spina bifida, congenital brain abnormality, and peri-natal hypoxic-ischaemic encephalopathy) should be immunised according to the recommended schedule; when there is a still evolving neurological problem , including poorly controlled epilepsy, immunisation should be deferred and the child referred to a specialist. Immunisation is recommended if a cause for the neurological disorder is identified. If a cause is not identified, immunisation should be deferred until the condition is stable. Impaired immune response and drugs affecting immune response Immune response to vaccines may be reduced in immunosuppressed patients, UKHSA advises consider seeking specialist advice.
Side effects
For all vaccines, general Common or very common Abdominal pain; appetite decreased; arthralgia; diarrhoea; dizziness; fatigue; fever; headache; lymphadenopathy; malaise; myalgia; nausea; skin reactions; vomiting Uncommon Hypersensitivity Side-effects For typhoid vaccine (inactivated) Common or very common Asthenia Frequency not known Asthma; shock
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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