Formulary
Toremifene: Indications, Dosing, Side Effects and Interactions
Toremifene clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Toremifene: Indications, Dosing, Side Effects and Interactions
Toremifene clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Hormone-dependent metastatic breast cancer in postmenopausal women**
- **Adult** (By Mouth): 60 mg daily.
Cautions
Avoid in Acute porphyrias ; history of severe thromboembolic disease
Contraindications
Bradycardia; electrolyte disturbances (particularly uncorrected hypokalaemia); endometrial hyperplasia; heart failure with reduced left-ventricular ejection fraction; history of arrhythmias; QT prolongation
Side effects
Common or very common Dizziness; fatigue; hot flush; hyperhidrosis; nausea; oedema; skin reactions; vaginal discharge; vomiting Uncommon Appetite decreased; constipation; depression; dyspnoea; headache; insomnia; thromboembolism; uterine disorders; weight increased Rare or very rare Alopecia; corneal opacity; endometrial cancer; hepatic disorders; uterine haemorrhage; vertigo Frequency not known Anaemia; leucopenia; thrombocytopenia Side-effects, further information Increased endometrial changes, including hyperplasia, polyps and cancer reported.
Interactions
**Severe interactions:**
- Based on these data, no clinically significant pharmacodynamic interaction with other medicinal products is expected, with exception of the following: For toremifene and fusidic acid displacement...
**Other interactions (6):**
- The safety of using ospemifene concomitantly with oestrogens or other SERMS, such as tamoxifen, toremifene, bazedoxifene and raloxifene, has not been studied and its concurrent use is not recommended.
- Thiazide diuretics may increase the risk of hypercalcaemia with toremifene.
- Examples include: Class IA antiarrhythmics (e.g.
- Examples of drugs or drug classes affected by rifampicin: Antiarrhythmics (e.g.
- Toremifene: For toremifene, which has a relatively high binding affinity for sugammadex and for which relatively high plasma concentrations might be present, some displacement of vecuronium or...
- Clinicians should be aware that the recovery of the T 4 /T 1 ratio to 0.9 could therefore be delayed in patients who have received toremifene on the same day of the operation.
Pregnancy
Avoid.
Breast feeding
Avoid.
Hepatic impairment
Manufacturer advises caution; avoid in severe hepatic failure (risk of decreased elimination).
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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