Formulary
Tirofiban: Indications, Dosing, Side Effects and Interactions
Tirofiban clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Tirofiban: Indications, Dosing, Side Effects and Interactions
Tirofiban clinical drug profile including indications, dosing, side effects, cautions and interactions.
Cautions
Active peptic ulcer (within 3 months); acute pericarditis; anaemia; aortic dissection; cardiogenic shock; discontinue if intra-aortic balloon pump necessary; discontinue if thrombolytic therapy necessary; discontinue immediately if serious or uncontrollable bleeding occurs; discontiue if emergency cardiac surgery necessary; elderly; faecal occult blood; haematuria; haemorrhagic retinopathy; low body-weight; major surgery within 3 months (avoid if within 6 weeks); organ biopsy or lithotripsy within last 2 weeks; puncture of non-compressible vessel within 24 hours; risk of bleeding; severe heart failure; severe trauma within 3 months (avoid if within 6 weeks); traumatic or protracted cardiopulmonary resuscitation within last 2 weeks; uncontrolled severe hypertension; vasculitis
Contraindications
Abnormal bleeding within 30 days; history of haemorrhagic stroke; history of intracranial disease; increased INR; increased prothrombin time; severe hypertension; stroke within 30 days; thrombocytopenia
Side effects
Common or very common Ecchymosis; fever; haemorrhage; headache; nausea; thrombocytopenia Frequency not known Intracranial haemorrhage
Interactions
**Other interactions (8):**
- The use of several platelet aggregation inhibitors increases the risk of bleeding, likewise their combination with heparin, warfarin and thrombolytics.
- The concomitant administration of Tirofiban and ASA increases the inhibition of platelet aggregation to a greater extent than ASA alone, as measured by ex vivo APD-induced platelet aggregation test.
- The concomitant administration of Tirofiban and unfractionated heparin increases the prolongation of the bleeding time to a greater extent as compared to unfractionated heparin alone.
- With the concurrent use of Tirofiban, unfractionated heparin, ASA, and clopidogrel there was a comparable incidence of bleeding than when only unfractionated heparin, ASA, and clopidogrel were used...
- Tirofiban prolonged bleeding time; however, the combined administration of Tirofiban and ticlopidine did not additionally affect bleeding time.
- Concomitant use of warfarin with Tirofiban plus heparin was associated with an increased risk of bleeding.
Pregnancy
Manufacturer advises use only if potential benefit outweighs risk-no information available.
Breast feeding
Manufacturer advises avoid-no information available.
Hepatic impairment
Manufacturer advises caution in mild to moderate hepatic failure; avoid in severe hepatic failure (no information available).
Renal impairment
Monitor carefully if creatinine clearance less than 60 mL/minute (increased risk of bleeding). M Dose adjustments Use half normal dose if creatinine clearance less than 30 mL/minute (consult product literature). M See Prescribing in renal impairment .
Medicinal forms
Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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