Formulary
Temocillin: Indications, Dosing, Side Effects and Interactions
The penicillins are bactericidal and act by interfering with bacterial cell wall synthesis.
MedNext Academy | 3 min read
Temocillin: Indications, Dosing, Side Effects and Interactions
The penicillins are bactericidal and act by interfering with bacterial cell wall synthesis.
Drug action
The penicillins are bactericidal and act by interfering with bacterial cell wall synthesis. They diffuse well into body tissues and fluids, but penetration into the cerebrospinal fluid is poor except when the meninges are inflamed. They are excreted in the urine in therapeutic concentrations.
Indications and dose
**Septicaemia,Urinary-tract infections,Lower respiratory-tract infections caused by susceptible Gram-negative bacteria**
- **Adult** (By Intramuscular Injection, Or By Slow Intravenous Injection, Or By Intravenous Infusion): (consult product literature).
Cautions
History of allergy Cautions For temocillin Accumulation of sodium from injection can occur with high doses
Side effects
Common or very common Diarrhoea; hypersensitivity; nausea; skin reactions; thrombocytopenia; vomiting Uncommon Arthralgia; leucopenia Rare or very rare Agranulocytosis; angioedema; haemolytic anaemia; hepatic disorders; nephritis tubulointerstitial; neutropenia; pseudomembranous enterocolitis; seizure; severe cutaneous adverse reactions (SCARs) Side-effects, further information Diarrhoea frequently occurs during oral penicillin therapy. It is most common with broad-spectrum penicillins, which can cause antibiotic-associated colitis. Side-effects For temocillin Frequency not known Fever; myalgia; nervous system disorder; thrombophlebitis
Pregnancy
Not known to be harmful.
Breast feeding
Trace amounts in milk.
Renal impairment
Accumulation of sodium from injection can occur in patients with renal failure. Dose adjustments Manufacturer advises reduce usual dose to 1 g every 12 hours if creatinine clearance 30-60 mL/minute; reduce usual dose to 1 g every 24 hours if creatinine clearance 10-30 mL/minute; reduce usual dose to 1 g every 48 hours or 500 mg every 24 hours if creatinine clearance less than 10 mL/minute; no information available to recommend dose adjustments with higher daily dose for use in critically ill patients. See Prescribing in renal impairment .
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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