Formulary
Sotrovimab: Indications, Dosing, Side Effects and Interactions
Sotrovimab is an engineered human immunoglobulin monoclonal antibody that binds to the spike protein receptor binding domain of SARS-CoV-2, which prevents the...
MedNext Academy | 3 min read
Sotrovimab: Indications, Dosing, Side Effects and Interactions
Sotrovimab is an engineered human immunoglobulin monoclonal antibody that binds to the spike protein receptor binding domain of SARS-CoV-2, which prevents the...
Drug action
Sotrovimab is an engineered human immunoglobulin monoclonal antibody that binds to the spike protein receptor binding domain of SARS-CoV-2, which prevents the virus from entering human cells.
Indications and dose
**COVID-19 in patients who do not require oxygen supplementation and are at an increased risk of severe COVID-19 infection [if nirmatrelvir with ritonavir inappropriate]**
- **Adult** (By Intravenous Infusion): 500 mg for 1 dose, to be initiated as soon as possible after diagnosis and within 5 days of symptom onset.
**COVID-19 in patients who do not require oxygen supplementation and are at an increased risk of severe COVID-19 infection for sotrovimab**
- **Child 12-17 years (body-weight 40 kg and above)** (By intravenous infusion): 500 mg for 1 dose, to be initiated as soon as possible after diagnosis and within 5 days of symptom onset.
Side effects
Common or very common Bronchospasm; hypersensitivity; infusion related reaction; skin reactions
Interactions
**Other interactions (1):**
- Concomitant administration of sotrovimab with COVID-19 vaccines has not been studied.
Pregnancy
Use only if potential benefit outweighs risk-no information available. M
Breast feeding
Specialist sources indicate use with caution-no information available. Large molecular weight suggests limited excretion into milk. Monitor breast-fed infants for adequate feeding and hypersensitivity reactions.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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