Formulary
Sodium zirconium cyclosilicate: Indications, Dosing, Side Effects and Interactions
For sodium zirconium cyclosilicate Sodium zirconium cyclosilicate is a non-absorbed cation-exchange compound that acts as a selective potassium binder in the...
MedNext Academy | 3 min read
Sodium zirconium cyclosilicate: Indications, Dosing, Side Effects and Interactions
For sodium zirconium cyclosilicate Sodium zirconium cyclosilicate is a non-absorbed cation-exchange compound that acts as a selective potassium binder in the...
Drug action
For sodium zirconium cyclosilicate Sodium zirconium cyclosilicate is a non-absorbed cation-exchange compound that acts as a selective potassium binder in the gastro-intestinal tract.
Indications and dose
**Hyperkalaemia**
- **Adult** (By Mouth): Initially 10 g 3 times a day, for up to 72 hours, followed by maintenance 5 g once daily, adjusted according to serum-potassium concentrations. The usual maintenance dose range is 5 g once every other day to 10 g once daily.
Cautions
For sodium zirconium cyclosilicate Abdominal X-ray (sodium zirconium cyclosilicate may be opaque to X-rays)
Side effects
For sodium zirconium cyclosilicate Common or very common Fluid imbalance; oedema; peripheral swelling Frequency not known Constipation; nausea
Interactions
**Other interactions (4):**
- In a clinical drug-drug interaction study conducted in healthy subjects co-administration of sodium zirconium cyclosilicate with amlodipine, clopidogrel, atorvastatin, furosemide, glipizide,...
- Examples of medicinal products that should be administered 2 hours before or after sodium zirconium cyclosilicate to avoid possible raised gastric pH drug interaction are azole antifungals...
- In another drug-drug interaction study in healthy volunteers, co-administration of Lokelma 15 g with tacrolimus 5 mg resulted in a decreased tacrolimus AUC and C max by 37% and 29% respectively.
- Therefore, tacrolimus should be taken at least 2 hours before or after Lokelma.
Pregnancy
For sodium zirconium cyclosilicate Manufacturer advises avoid-limited information; animal studies do not indicate toxicity.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Sodium zirconium cyclosilicate in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

