Formulary
Selumetinib: Indications, Dosing, Side Effects and Interactions
Selumetinib selectively inhibits the mitogen-activated protein kinase (MAPK) pathway, specifically mitogen-activated extracellular kinases MEK 1 and 2,...
MedNext Academy | 3 min read
Selumetinib: Indications, Dosing, Side Effects and Interactions
Selumetinib selectively inhibits the mitogen-activated protein kinase (MAPK) pathway, specifically mitogen-activated extracellular kinases MEK 1 and 2,...
Drug action
Selumetinib selectively inhibits the mitogen-activated protein kinase (MAPK) pathway, specifically mitogen-activated extracellular kinases MEK 1 and 2, thereby inhibiting the proliferation and survival of tumour cells.
Indications and dose
**Inoperable plexiform neurofibromas in patients with neurofibromatosis type 1 (initiated by a specialist) for selumetinib**
- **Child 3-17 years** (By mouth): 25 mg/m2 twice daily (max. per dose 50 mg), each dose should be rounded to the nearest 5 or 10 mg and given about 12 hours apart, for further dosing advice based on body surface area-consult product literature, for dose adjustments, treatment interruption, or discontinuation due to side-effects-consult product literature.
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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