Formulary
Seladelpar: Indications, Dosing, Side Effects and Interactions
Seladelpar is a peroxisome proliferator-activated receptor (PPAR) delta agonist that decreases bile acid synthesis, reducing inflammation and scarring in the...
MedNext Academy | 3 min read
Seladelpar: Indications, Dosing, Side Effects and Interactions
Seladelpar is a peroxisome proliferator-activated receptor (PPAR) delta agonist that decreases bile acid synthesis, reducing inflammation and scarring in the...
Drug action
Seladelpar is a peroxisome proliferator-activated receptor (PPAR) delta agonist that decreases bile acid synthesis, reducing inflammation and scarring in the liver.
Indications and dose
**Primary biliary cholangitis [in combination with ursodeoxycholic acid when response to ursodeoxycholic acid has been inadequate, or as monotherapy in patients intolerant of ursodeoxycholic acid]**
- **Adult** (By Mouth): 10 mg once daily.
Contraindications
Complete biliary obstruction
Side effects
Common or very common Gastrointestinal discomfort; headache; nausea
Pregnancy
Avoid (limited information available). M
Breast feeding
Avoid (no information available). M
Hepatic impairment
Avoid in decompensated cirrhosis. Caution in moderate or severe impairment; consider stopping if patient progresses to this during treatment (increased risk of exposure). M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Seladelpar in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

