Formulary
Rupatadine: Indications, Dosing, Side Effects and Interactions
Rupatadine is a second generation non-sedating antihistamine.
MedNext Academy | 3 min read
Rupatadine: Indications, Dosing, Side Effects and Interactions
Rupatadine is a second generation non-sedating antihistamine.
Drug action
Rupatadine is a second generation non-sedating antihistamine.
Indications and dose
**Symptomatic relief of allergic rhinitis and urticaria**
- **Child** (By Mouth Using Tablets): 12-17 years 10 mg once daily.
- **Adult** (By Mouth Using Tablets): 10 mg once daily.
**Symptomatic relief of allergic rhinitis and urticaria for rupatadine**
- **Child 12-17 years** (By mouth using tablets): 10 mg once daily.
- **Child 2-11 years (body-weight 10-24 kg)** (By mouth using oral solution): 2.5 mg once daily.
- **Child 2-11 years (body-weight 25 kg and above)** (By mouth using oral solution): 5 mg once daily.
Cautions
Elderly-limited information available (in adults); history of QT-interval prolongation; predisposition to arrhythmia; uncorrected hypokalaemia
Side effects
Common or very common Asthenia; dizziness; drowsiness; dry mouth; headache Uncommon Appetite increased; arthralgia; back pain; concentration impaired; constipation; cough; diarrhoea; dry throat; eosinophilia (in children); epistaxis; fever; gastrointestinal discomfort; increased risk of infection; irritability; malaise; myalgia; nasal dryness; nausea; neutropenia (in children); night sweats (in children); oropharyngeal pain; skin reactions; thirst; vomiting; weight increased Rare or very rare Palpitations; tachycardia Side-effects, further information Non-sedating antihistamines such as rupatadine cause less sedation and psychomotor impairment than the older antihistamines, but can still occur; sedation is generally minimal. This is because non-sedating antihistamines penetrate the blood brain barrier to a much lesser extent.
Pregnancy
Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity.
Breast feeding
Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.
Hepatic impairment
Manufacturer advises avoid (no information available).
Renal impairment
Manufacturer advises avoid-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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