Formulary
Romosozumab: Indications, Dosing, Side Effects and Interactions
Romosozumab is a humanised monoclonal antibody that inhibits sclerostin, thereby increasing bone formation and decreasing bone resorption.
MedNext Academy | 3 min read
Romosozumab: Indications, Dosing, Side Effects and Interactions
Romosozumab is a humanised monoclonal antibody that inhibits sclerostin, thereby increasing bone formation and decreasing bone resorption.
Drug action
Romosozumab is a humanised monoclonal antibody that inhibits sclerostin, thereby increasing bone formation and decreasing bone resorption.
Indications and dose
**Severe osteoporosis in postmenopausal women at increased risk of fractures (specialist use only)**
- **Adult** (By Subcutaneous Injection): 210 mg once a month for 12 months, supplement with calcium and vitamin D, to be administered as two consecutive 105 mg injections at different injection sites into the thigh, abdomen or upper arm.
Cautions
Risk factors for cardiovascular disease; risk factors for osteonecrosis of the jaw-consider temporary interruption of romosozumab if occurs during treatment
Contraindications
History of myocardial infarction or stroke-discontinue if occurs during treatment; hypocalcaemia
Side effects
Common or very common Arthralgia; headache; hypersensitivity; increased risk of infection; muscle spasms; neck pain; skin reactions Uncommon Cataract; hypocalcaemia; myocardial infarction; stroke Rare or very rare Angioedema Frequency not known Atypical femur fracture; cardiovascular event; osteonecrosis of jaw
Interactions
**Other interactions (2):**
- No drug interaction studies have been performed with romosozumab.
- No pharmacokinetic drug interactions are expected with romosozumab.
Renal impairment
Manufacturer advises monitor serum calcium concentration in patients with severe renal impairment, or in those receiving dialysis-increased risk of hypocalcaemia.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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