Formulary
Rizatriptan: Indications, Dosing, Side Effects and Interactions
Rizatriptan clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Rizatriptan: Indications, Dosing, Side Effects and Interactions
Rizatriptan clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Treatment of acute migraine**
- **Adult** (By Mouth): 10 mg, dose to be taken as soon as possible after onset, followed by 10 mg after 2 hours if required, dose to be taken only if migraine recurs (patient not responding to initial dose should not take second dose for same attack); maximum 20 mg per day.
Cautions
Conditions which predispose to coronary artery disease; elderly
Contraindications
Coronary vasospasm; ischaemic heart disease; peripheral vascular disease; previous cerebrovascular accident; previous myocardial infarction; previous transient ischaemic attack; Prinzmetal's angina; severe hypertension; uncontrolled hypertension
Side effects
Common or very common Alertness decreased; asthenia; diarrhoea; dizziness; drowsiness; dry mouth; dyspepsia; feeling abnormal; headache; insomnia; musculoskeletal stiffness; nausea; pain; palpitations; sensation abnormal; throat complaints; vasodilation; vomiting Uncommon Angioedema; arrhythmias; ataxia; disorientation; dyspnoea; face oedema; hyperhidrosis; hypertension; muscle weakness; myalgia; nervousness; skin reactions; syncope; taste altered; thirst; tongue swelling; tremor; vertigo; vision blurred Rare or very rare Hypersensitivity; stroke; wheezing Frequency not known Colitis ischaemic; myocardial infarction; myocardial ischaemia; peripheral vascular disease; seizure; serotonin syndrome; toxic epidermal necrolysis Side-effects, further information Discontinue if symptoms of heat, heaviness, pressure or tightness (including throat and chest) occur.
Interactions
**Other interactions (2):**
- Triptans Additive vasoconstriction may occur when ergometrine is concomitantly given with triptans (e.g.
- Propranolol may increase plasma concentration of rizatriptan when taken concomitantly.
Pregnancy
There is limited experience of using 5HT 1 -receptor agonists during pregnancy; manufacturers advise that they should be avoided unless the potential benefit outweighs the risk.
Breast feeding
Present in milk in animal studies-withhold breast-feeding for 24 hours.
Hepatic impairment
Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment (no information available). Dose adjustments Manufacturer advises dose reduction to 5 mg in mild to moderate impairment.
Renal impairment
Avoid in severe impairment. M Dose adjustments Reduce dose to 5 mg in mild to moderate impairment. M
Medicinal forms
Tablet,Tablet
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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