Formulary
Risedronate sodium: Indications, Dosing, Side Effects and Interactions
Bisphosphonates are adsorbed onto hydroxyapatite crystals in bone, slowing both their rate of growth and dissolution, and therefore reducing the rate of bone...
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Risedronate sodium: Indications, Dosing, Side Effects and Interactions
Bisphosphonates are adsorbed onto hydroxyapatite crystals in bone, slowing both their rate of growth and dissolution, and therefore reducing the rate of bone...
Drug action
Bisphosphonates are adsorbed onto hydroxyapatite crystals in bone, slowing both their rate of growth and dissolution, and therefore reducing the rate of bone turnover.
Indications and dose
**Paget's disease of bone**
- **Adult** (By Mouth): 30 mg daily for 2 months, course may be repeated if necessary after at least 2 months.
**Treatment of postmenopausal osteoporosis to reduce risk of vertebral or hip fractures**
- **Adult** (By Mouth): (female) 5 mg daily, alternatively 35 mg once weekly.
**Prevention of osteoporosis (including corticosteroid-induced osteoporosis) in postmenopausal women**
- **Adult** (By Mouth): (female) 5 mg daily.
**Treatment of osteoporosis in men at high risk of fractures**
- **Adult** (By Mouth): (male) 35 mg once weekly.
**Osteoporosis (due to osteogenesis imperfecta and other causes) (specialist use only), Hypercalcaemia (specialist use only) for risedronate sodium**
- **Child** (By mouth): (consult local protocol).
Cautions
Cautions, further information Elderly With oral use: Screening Tool of Older Persons' potentially inappropriate Prescriptions (STOPP) criteria to aid medication reviews (see Prescribing in the elderly for information): potentially inappropriate in patients with a current or recent history of upper gastro-intestinal disease or bleeding (risk of relapse/exacerbation of oesophagitis, oesophageal ulcer, or oesophageal stricture). Cautions For risedronate sodium Atypical femoral fractures; oesophageal abnormalities; other factors which delay transit or emptying (e.g. stricture or achalasia); upper gastro-intestinal disorders
Contraindications
Hypocalcaemia
Side effects
Common or very common Alopecia; anaemia; appetite decreased; arthralgia; asthenia; chills; constipation; diarrhoea; dizziness; dysphagia; electrolyte imbalance; eye inflammation; fever; gastritis; gastrointestinal discomfort; headache; influenza like illness; malaise; myalgia; nausea; oesophageal ulcer (discontinue); oesophagitis (discontinue); pain; peripheral oedema; renal impairment; skin reactions; taste altered; vomiting Uncommon Anaphylactic reaction; angioedema; bronchospasm; oesophageal stenosis (discontinue); osteonecrosis Rare or very rare Atypical femur fracture; Stevens-Johnson syndrome Side-effects For risedronate sodium Uncommon Gastrointestinal disorders Rare or very rare Glossitis Frequency not known Amblyopia; apnoea; chest pain; corneal lesion; dry eye; hypersensitivity; hypersensitivity vasculitis; increased risk of infection; leg cramps; liver disorder; muscle weakness; neoplasms; nocturia; tinnitus; toxic epidermal necrolysis; weight decreased
Pregnancy
Avoid.
Breast feeding
Avoid.
Renal impairment
Avoid if creatinine clearance less than 30 mL/minute. M See Prescribing in renal impairment .
Medicinal forms
Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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