Formulary
Riluzole: Indications, Dosing, Side Effects and Interactions
Riluzole clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Riluzole: Indications, Dosing, Side Effects and Interactions
Riluzole clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**To extend life in patients with amyotrophic lateral sclerosis, initiated by specialist experienced in the management of motor neurone disease**
- **Adult** (By Mouth): 50 mg twice daily.
Cautions
Interstitial lung disease Cautions, further information Interstitial lung disease Perform chest radiography if symptoms such as dry cough or dyspnoea develop; discontinue if interstitial lung disease is diagnosed. M
Contraindications
Acute porphyrias
Side effects
Common or very common Abdominal pain; asthenia; diarrhoea; dizziness; drowsiness; headache; nausea; oral disorders; pain; tachycardia; vomiting Uncommon Anaemia; angioedema; interstitial lung disease; pancreatitis Frequency not known Hepatitis; neutropenia; rash Side-effects, further information White blood cell counts should be determined in febrile illness; neutropenia requires discontinuation of riluzole.
Interactions
**Other interactions (3):**
- There have been no clinical studies to evaluate the interactions of riluzole with other medicinal products.
- In vitro studies using human liver microsomal preparations suggest that CYP 1A2 is the principal isozyme involved in the initial oxidative metabolism of riluzole.
- Inhibitors of CYP 1A2 (e.g.
Pregnancy
Avoid-no information available.
Breast feeding
Avoid-no information available.
Hepatic impairment
Avoid in hepatic disease or when baseline transaminases greater than 3 times the upper limit of normal. Caution in patients with a history of abnormal liver function or with slightly elevated transaminases (up to 3 times the upper limit of normal).
Renal impairment
Avoid-no information available. M
Medicinal forms
Solution,Tablet,Film,Suspension
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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