Formulary
Relugolix with estradiol and norethisterone acetate: Indications, Dosing, Side Effects and Interactions
For relugolix with estradiol and norethisterone acetate Relugolix is a non-peptide gonadotrophin-releasing hormone (GnRH) receptor antagonist that prevents...
MedNext Academy | 3 min read
Relugolix with estradiol and norethisterone acetate: Indications, Dosing, Side Effects and Interactions
For relugolix with estradiol and norethisterone acetate Relugolix is a non-peptide gonadotrophin-releasing hormone (GnRH) receptor antagonist that prevents...
Drug action
For relugolix with estradiol and norethisterone acetate Relugolix is a non-peptide gonadotrophin-releasing hormone (GnRH) receptor antagonist that prevents follicular growth and development, thereby reducing production of oestrogen and progesterone. Relugolix is combined with the oestrogen estradiol to reduce symptoms related to lowered levels of oestrogen, and the progestogen norethisterone to counteract estradiol-induced endometrial hyperplasia.
Indications and dose
**Moderate to severe uterine fibroids (under expert supervision),Endometriosis (under expert supervision)**
- **Adult** (By Mouth): 1 tablet once daily, dose to be taken at around the same time each day, starting within 5 days of the onset of menstrual bleeding, consider discontinuing treatment when patient enters menopause.
Cautions
For relugolix with estradiol and norethisterone acetate History of depression (discontinue if severe depression recurs); risk factors for osteoporosis (dual X-ray absorptiometry (DXA) scan recommended before starting)
Contraindications
For relugolix with estradiol and norethisterone acetate Osteoporosis
Side effects
For relugolix with estradiol and norethisterone acetate Common or very common Alopecia; breast cyst; dyspepsia; hot flush; irritability; libido decreased; menstrual cycle irregularities; sweat changes; uterine haemorrhage Uncommon Uterine myoma expulsion Frequency not known Arterial thromboembolism; bone loss; uterine leiomyoma prolapse
Pregnancy
For relugolix with estradiol and norethisterone acetate Avoid-relugolix showed embryotoxicity in animal studies. M
Breast feeding
For relugolix with estradiol and norethisterone acetate Avoid during treatment and for 2 weeks following last treatment-relugolix present in milk in animal studies. M
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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