Formulary
Quinagolide: Indications, Dosing, Side Effects and Interactions
Quinagolide is a non-ergot dopamine D 2 agonist.
MedNext Academy | 3 min read
Quinagolide: Indications, Dosing, Side Effects and Interactions
Quinagolide is a non-ergot dopamine D 2 agonist.
Drug action
Quinagolide is a non-ergot dopamine D 2 agonist.
Indications and dose
**Hyperprolactinaemia**
- **Adult** (By Mouth): Initially 25 micrograms once daily for 3 days, dose to be taken at bedtime, increased in steps of 25 micrograms every 3 days; usual dose 75-150 micrograms daily, for doses higher than 300 micrograms daily increase in steps of 75-150 micrograms at intervals of not less than 4 weeks.
Cautions
Acute porphyrias ; history of psychotic illness; history of serious mental disorders Cautions, further information Hyperprolactinemic patients In hyperprolactinaemic patients, the source of the hyperprolactinaemia should be established (i.e. exclude pituitary tumour before treatment).
Side effects
Common or very common Abdominal pain; appetite decreased; constipation; diarrhoea; dizziness; fatigue; flushing; headache; hypotension; insomnia; nasal congestion; nausea; oedema; syncope; vomiting Rare or very rare Acute psychosis; drowsiness
Interactions
**Other interactions (1):**
- Contra-indicated drug combinations: Antiparkinsonism dopaminergic agonists agents (amantadine, apomorphine, bromocriptine, cabergoline, entacapone, lisuride, pergolide, piribedil, pramiprexole,...
Pregnancy
Discontinue when pregnancy confirmed unless medical reason for continuing (specialist advice needed).
Breast feeding
Suppresses lactation.
Hepatic impairment
Manufacturer advises avoid (no information available).
Renal impairment
Avoid (no information available). M
Medicinal forms
Tablet
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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