Formulary
Prucalopride: Indications, Dosing, Side Effects and Interactions
A selective serotonin 5HT 4 -receptor agonist with prokinetic properties.
MedNext Academy | 3 min read
Prucalopride: Indications, Dosing, Side Effects and Interactions
A selective serotonin 5HT 4 -receptor agonist with prokinetic properties.
Drug action
A selective serotonin 5HT 4 -receptor agonist with prokinetic properties.
Indications and dose
**Chronic constipation when other laxatives fail to provide an adequate response**
- **Adult** (By Mouth): 2 mg once daily, review treatment if no response after 4 weeks.
- **Elderly** (By Mouth): Initially 1 mg once daily, increased if necessary to 2 mg once daily, review treatment if no response after 4 weeks.
Cautions
History of arrhythmias; history of ischaemic heart disease
Contraindications
Crohn's disease; intestinal obstruction; intestinal perforation; toxic megacolon; ulcerative colitis
Side effects
Common or very common Appetite decreased; diarrhoea; dizziness; fatigue; gastrointestinal discomfort; gastrointestinal disorders; headache; nausea; vomiting Uncommon Anorectal haemorrhage; fever; malaise; palpitations; tremor; urinary frequency increased Side-effects, further information Side-effects generally occur at the start of treatment and are usually transient.
Pregnancy
Manufacturer advises avoid-limited data available.
Breast feeding
Manufacturer advises avoid-present in milk.
Hepatic impairment
Manufacturer advises caution in severe impairment (risk of increased exposure, limited information available). Dose adjustments Manufacturer advises initial dose of 1 mg once daily in severe impairment; if tolerated this may be increased to 2 mg once daily.
Renal impairment
Dose adjustments Reduce dose to 1 mg daily if eGFR less than 30 mL/minute/1.73 m 2 . M See Prescribing in renal impairment .
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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