Formulary
Propiverine hydrochloride: Indications, Dosing, Side Effects and Interactions
Propiverine hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Propiverine hydrochloride: Indications, Dosing, Side Effects and Interactions
Propiverine hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Urinary frequency, urgency and incontinence associated with overactive bladder**
- **Adult** (By Mouth Using Immediate-Release Medicines): 15 mg 1-2 times a day, increased if necessary up to 15 mg 3 times a day.
- **Adult** (By Mouth Using Modified-Release Capsules): 30 mg once daily.
**Urinary frequency, urgency and incontinence associated with neurogenic bladder instability**
- **Adult** (By Mouth Using Immediate-Release Medicines): 15 mg 3 times a day.
Cautions
For all antimuscarinics (systemic) Acute myocardial infarction; arrhythmias (may be worsened); autonomic neuropathy; cardiac insufficiency (due to association with tachycardia); cardiac surgery (due to association with tachycardia); conditions characterised by tachycardia; congestive heart failure (may be worsened); coronary artery disease (may be worsened); diarrhoea; elderly (especially if frail); gastro-oesophageal reflux disease; hiatus hernia with reflux oesophagitis; hypertension; hyperthyroidism (due to association with tachycardia); individuals susceptible to angle-closure glaucoma; prostatic hyperplasia; pyrexia; ulcerative colitis Cautions, further information Elderly Screening Tool of Older Persons' potentially inappropriate Prescriptions (STOPP) criteria to aid medication reviews (see Prescribing in the elderly for information). Potentially inappropriate: if treating extrapyramidal side-effects of antipsychotic medications (risk of antimuscarinic toxicity) with delirium or dementia (risk of exacerbation of cognitive impairment), angle-closure glaucoma (contra-indicated; risk of acute exacerbation of glaucoma), or chronic prostatism (risk of urinary retention) if two or more antimuscarinic drugs prescribed concomitantly (risk of increased antimuscarinic toxicity)
Contraindications
For all antimuscarinics (systemic) Angle-closure glaucoma; gastro-intestinal obstruction; intestinal atony; myasthenia gravis (but some antimuscarinics may be used to decrease muscarinic side-effects of anticholinesterases); paralytic ileus; pyloric stenosis; severe ulcerative colitis; significant bladder outflow obstruction; toxic megacolon; urinary retention
Side effects
For all antimuscarinics (systemic) Common or very common Constipation; dizziness; drowsiness; dry mouth; dyspepsia; flushing; headache; nausea; palpitations; skin reactions; tachycardia; urinary disorders; vision disorders; vomiting Rare or very rare Angioedema; confusion (more common in elderly) Side-effects For propiverine hydrochloride Common or very common Abdominal pain; fatigue Uncommon Taste altered; tremor Rare or very rare Restlessness Frequency not known Hallucination
Pregnancy
Manufacturer advises avoid (restriction of skeletal development in animals ).
Breast feeding
Manufacturer advises avoid-present in milk in animal studies.
Hepatic impairment
Manufacturer advises caution in mild impairment; avoid in moderate to severe impairment (no information available).
Renal impairment
Use with caution. M Dose adjustments Max. daily dose 30 mg if creatinine clearance less than 30 mL/minute. M See Prescribing in renal impairment .
Medicinal forms
Tablet,Capsule
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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