Formulary
Propantheline bromide: Indications, Dosing, Side Effects and Interactions
Propantheline bromide clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Propantheline bromide: Indications, Dosing, Side Effects and Interactions
Propantheline bromide clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Adult enuresis,Hyperhidrosis,Symptomatic relief of gastro-intestinal disorders characterised by smooth muscle spasm**
- **Adult** (By Mouth): enuresis, Hyperhidrosis, Symptomatic relief of gastro-intestinal disorders characterised by smooth muscle spasm 15 mg 3 times a day, dose to be taken at least one hour before food and 30 mg, dose to be taken at bedtime; maximum 120 mg per day.
**Symptomatic relief of gastro-intestinal disorders characterised by smooth muscle spasm for propantheline bromide**
- **Child 1 month-11 years** (By mouth): 300 micrograms/kg 3-4 times a day (max. per dose 15 mg), dose to be taken at least one hour before food.
- **Child 12-17 years** (By mouth): 15 mg 3 times a day, dose to be taken at least one hour before food and 30 mg, dose to be taken at night; maximum 120 mg per day.
Cautions
For all antimuscarinics (systemic) Acute myocardial infarction; arrhythmias (may be worsened); autonomic neuropathy; cardiac insufficiency (due to association with tachycardia); cardiac surgery (due to association with tachycardia); conditions characterised by tachycardia; congestive heart failure (may be worsened); coronary artery disease (may be worsened); diarrhoea; elderly (especially if frail); gastro-oesophageal reflux disease; hiatus hernia with reflux oesophagitis; hypertension; hyperthyroidism (due to association with tachycardia); individuals susceptible to angle-closure glaucoma; prostatic hyperplasia; pyrexia; ulcerative colitis Cautions, further information Elderly Screening Tool of Older Persons' potentially inappropriate Prescriptions (STOPP) criteria to aid medication reviews (see Prescribing in the elderly for information). Potentially inappropriate: if treating extrapyramidal side-effects of antipsychotic medications (risk of antimuscarinic toxicity) with delirium or dementia (risk of exacerbation of cognitive impairment), angle-closure glaucoma (contra-indicated; risk of acute exacerbation of glaucoma), or chronic prostatism (risk of urinary retention) if two or more antimuscarinic drugs prescribed concomitantly (risk of increased antimuscarinic toxicity)
Contraindications
For all antimuscarinics (systemic) Angle-closure glaucoma; gastro-intestinal obstruction; intestinal atony; myasthenia gravis (but some antimuscarinics may be used to decrease muscarinic side-effects of anticholinesterases); paralytic ileus; pyloric stenosis; severe ulcerative colitis; significant bladder outflow obstruction; toxic megacolon; urinary retention
Side effects
For all antimuscarinics (systemic) Common or very common Constipation; dizziness; drowsiness; dry mouth; dyspepsia; flushing; headache; nausea; palpitations; skin reactions; tachycardia; urinary disorders; vision disorders; vomiting Rare or very rare Angioedema; confusion (more common in elderly) Side-effects For propantheline bromide Frequency not known Arrhythmias; bronchial secretion decreased; mydriasis
Interactions
**Other interactions (12):**
- The absorption of paracetamol has been reported to be reduced and retarded.
- Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.
- Antidepressants: increased risk of antimuscarinic side effects when antimuscarinics are given with MAOIs or tricyclics or tricyclic-related antidepressants.
- Antifungals: antimuscarinics reduce absorption of ketoconazole.
- Antihistamines: increased risk of antimuscarinic side effects when antimuscarinics are given with antihistamines.
- Anti-infectives: the absorption of nitrofurantoin has been reported to be enhanced.
Pregnancy
Manufacturer advises avoid unless essential-no information available.
Breast feeding
May suppress lactation.
Hepatic impairment
Manufacturer advises caution.
Renal impairment
Manufacturer advises caution.
Medicinal forms
Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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