Formulary
Pizotifen: Indications, Dosing, Side Effects and Interactions
Pizotifen clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Pizotifen: Indications, Dosing, Side Effects and Interactions
Pizotifen clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Prevention of vascular headache,Prevention of classical migraine,Prevention of common migraine,Prevention of cluster headache**
- **Adult** (By Mouth): Initially 500 micrograms once daily, then increased to 1.5 mg once daily, dose to be increased gradually and taken at night, alternatively increased to 1.5 mg daily in 3 divided doses, doses to be increased gradually; increased if necessary up to 4.5 mg daily (max. per dose 3 mg).
**Prophylaxis of migraine**
- **Child** (By Mouth): 5-17 years Initially 500 micrograms once daily, dose to be taken at night, then increased if necessary up to 1.5 mg daily in divided doses, dose to be increased gradually, max. single dose (at night) 1 mg.
**Prophylaxis of migraine for pizotifen**
- **Child 5-17 years** (By mouth): Initially 500 micrograms once daily, dose to be taken at night, then increased if necessary up to 1.5 mg daily in divided doses, dose to be increased gradually, max. single dose (at night) 1 mg.
Cautions
Avoid abrupt withdrawal; history of epilepsy; susceptibility to angle-closure glaucoma; urinary retention
Contraindications
Acute porphyrias
Side effects
Common or very common Appetite increased; dizziness; drowsiness; dry mouth; fatigue; nausea; weight increased Uncommon Constipation Rare or very rare Aggression; anxiety; arthralgia; central nervous system stimulation; depression; hallucination; muscle complaints; paraesthesia; seizure; skin reactions; sleep disorders Frequency not known Hepatic disorders
Interactions
**Other interactions (3):**
- There is no evidence that concomitant use of migraine prophylactic medications has any effect on the efficacy or unwanted effects of zolmitriptan (for example beta blockers, oral dihydroergotamine,...
- Summary of Results from Additional Clinical Pharmacokinetic Drug Interaction Studies Concomitant Drug Concomitant Drug Concentration a Topiramate Concentration a Amitriptyline 20% increase in C...
- There is no evidence of interactions with propranolol, flunarizine, pizotifen or alcohol.
Pregnancy
Avoid unless potential benefit outweighs risk.
Breast feeding
Amount probably too small to be harmful, but manufacturer advises avoid.
Hepatic impairment
Manufacturer advises caution. Dose adjustments Manufacturer advises consider dose reduction.
Renal impairment
Use with caution. M Dose adjustments Consider dose reduction. M
Medicinal forms
Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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