Formulary
Phenoxybenzamine hydrochloride: Indications, Dosing, Side Effects and Interactions
Phenoxybenzamine hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Phenoxybenzamine hydrochloride: Indications, Dosing, Side Effects and Interactions
Phenoxybenzamine hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Hypertension in phaeochromocytoma**
- **Adult** (By Mouth): Initially 10 mg daily, increased in steps of 10 mg daily until hypertension controlled or treatment not tolerated; maintenance 1-2 mg/kg daily in 2 divided doses.
**Hypertension in phaeochromocytoma for phenoxybenzamine hydrochloride**
- **Child** (By mouth): 0.5-1 mg/kg twice daily, adjusted according to response.
Cautions
Avoid in Acute porphyrias ; carcinogenic in animals ; cerebrovascular disease; congestive heart failure; elderly; severe ischaemic heart disease
Contraindications
During recovery period after myocardial infarction (usually 3-4 weeks); history of cerebrovascular accident
Side effects
Frequency not known Abdominal distress; dizziness; ejaculation failure; fatigue; miosis; nasal congestion; postural hypotension; reflex tachycardia
Pregnancy
Hypotension may occur in newborn.
Breast feeding
May be present in milk.
Renal impairment
Use with caution. M
Medicinal forms
Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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