Formulary
Pentoxifylline: Indications, Dosing, Side Effects and Interactions
Pentoxifylline clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Pentoxifylline: Indications, Dosing, Side Effects and Interactions
Pentoxifylline clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Peripheral vascular disease,Venous leg ulcer (adjunct)**
- **Adult** (By Mouth): 400 mg 2-3 times a day.
Cautions
Avoid in Acute porphyrias ; coronary artery disease; hypotension
Contraindications
Acute myocardial infarction; cerebral haemorrhage; extensive retinal haemorrhage; severe cardiac arrhythmias
Side effects
Frequency not known Agitation; angina pectoris; angioedema; arrhythmias; bronchospasm; cholestasis; constipation; diarrhoea; dizziness; gastrointestinal discomfort; gastrointestinal disorder; haemorrhage; headache; hot flush; hypersalivation; hypotension; leucopenia; meningitis aseptic; nausea; neutropenia; skin reactions; sleep disorder; thrombocytopenia; vomiting
Interactions
**Other interactions (10):**
- High doses of Pentoxifylline injection have been shown, in rare cases, to intensify the hypoglycaemic action of insulin and oral hypoglycaemic agents.
- However, no effect on insulin release has been observed with Pentoxifylline following oral administration.
- Post-marketing cases of increased anti-coagulant activity have been reported in patients concomitantly treated with pentoxifylline and anti-vitamin K.
- Monitoring of anti-coagulant activity in these patients is recommended when pentoxifylline is introduced or the dose is changed.
- Pentoxifylline may potentiate the effect of anti-hypertensive agents and the dosage of the latter may need to be reduced.
- Concomitant administration of pentoxifylline and theophylline may increase theophylline levels in some patients.
Pregnancy
Manufacturer advises avoid-no information available.
Breast feeding
Present in milk-manufacturer advises use only if potential benefit outweighs risk.
Hepatic impairment
Manufacturer advises caution in severe impairment. Dose adjustments Manufacturer advises consider dose reduction in severe impairment.
Renal impairment
Dose adjustments Reduce dose by 30-50% if creatinine clearance less than 30 mL/minute. M See Prescribing in renal impairment .
Medicinal forms
Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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