Formulary
Pentostatin [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Pentostatin [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Pentostatin [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Pentostatin [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Hairy cell leukaemia**
- **Adult** (By Intravenous Injection, Or By Intravenous Infusion): Specialist drug - access specialist resources for dosing information.
Side effects
For pentostatin [Specialist drug] Common or very common Agranulocytosis; alopecia; amenorrhoea; anaemia; angina pectoris; anxiety; appetite decreased; arrhythmias; arthritis; asthenia; asthma; atrioventricular block; blood disorder; bone disorder; bone marrow disorders; breast mass; cardiac arrest; chest pain; chills; confusion; constipation; cough; deafness; death; depersonalisation; depression; diarrhoea; dizziness; drowsiness; dry eye; dry mouth; dysarthria; dysphagia; dyspnoea; ear pain; electrolyte imbalance; embolism and thrombosis; emotional lability; eosinophilia; eye disorders; eye inflammation; eye pain; febrile neutropenia; fever; fluid imbalance; flushing; gastrointestinal discomfort; gastrointestinal disorders; gout; graft versus host disease; haemorrhage; hallucination; hangover; headaches; heart failure; hostility; hyperbilirubinaemia; hyperglycaemia; hyperhidrosis; hypersensitivity; hypertension; hypotension; increased risk of infection; influenza like illness; jaundice; joint disorders; leucopenia; lymphadenopathy; malaise; memory loss; meningism; movement disorders; muscle complaints; nausea; neoplasms; nephrolithiasis; nephropathy; nerve disorders; neurotoxicity (withhold or discontinue); oedema; oral disorders; pain; paralysis; pericardial effusion; photosensitivity reaction; pulmonary oedema; rash (withhold if severe); renal impairment; respiratory disorders; retinopathy; seborrhoea; seizures; sensation abnormal; sepsis; sexual dysfunction; skin reactions; sleep disorders; splenomegaly; syncope; taste altered; thinking abnormal; thrombocytopenia; tinnitus; tremor; urinary disorders; urogenital disorder; vasculitis; vertigo; vision disorders; vomiting; weight changes Uncommon Angioedema; capillary leak syndrome; cardiomyopathy; Clostridioides difficile colitis; cystitis; haemolytic anaemia; mucositis; multi organ failure; myocardial infarction; pure red cell aplasia; transplant failure; tumour lysis syndrome Rare or very rare Alveolar fibrosis; dementia; interstitial lung disease; pericarditis; shock; Stevens-Johnson syndrome; systemic inflammatory response syndrome Side-effects, further information Pentostatin can cause myelosuppression, immunosuppression, and a number of other side-effects that may be severe. Treatment should be withheld in patients who develop a severe rash, and withheld or discontinued in patients showing signs of neurotoxicity.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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