Formulary
Patisiran: Indications, Dosing, Side Effects and Interactions
Patisiran is a double-stranded small interfering RNA which reduces transthyretin production.
MedNext Academy | 3 min read
Patisiran: Indications, Dosing, Side Effects and Interactions
Patisiran is a double-stranded small interfering RNA which reduces transthyretin production.
Drug action
Patisiran is a double-stranded small interfering RNA which reduces transthyretin production.
Indications and dose
**Stage 1 or stage 2 polyneuropathy in patients with hereditary transthyretin amyloidosis (hATTR) (initiated under specialist supervision)**
- **Adult** (By Intravenous Infusion): 300 micrograms/kg every 3 weeks (max. per dose 30 mg), dosage is based on actual body weight, for information on premedication, vitamin A supplementation, and missed doses-consult product literature.
Side effects
Common or very common Arthralgia; dyspepsia; dyspnoea; erythema; increased risk of infection; infusion related reaction; muscle spasms; peripheral oedema; vertigo Frequency not known Vitamin A deficiency
Pregnancy
Manufacturer advises avoid unless essential (limited information available)-potential teratogenic risk due to unbalanced vitamin A levels, consult product literature.
Breast feeding
Manufacturer advises avoid-present in milk in animal studies.
Hepatic impairment
Manufacturer advises caution in moderate or severe impairment (no information available).
Renal impairment
Manufacturer advises caution in severe impairment (no information available).
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Patisiran in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

