Formulary
Paricalcitol: Indications, Dosing, Side Effects and Interactions
Paricalcitol clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Paricalcitol: Indications, Dosing, Side Effects and Interactions
Paricalcitol clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Prevention and treatment of secondary hyperparathyroidism associated with chronic kidney disease**
- **Adult** (By Mouth): (consult product literature).
**Prevention and treatment of secondary hyperparathyroidism associated with chronic kidney disease for paricalcitol**
- **Child 10-17 years** (By mouth): (consult product literature).
Contraindications
D and analogues (systemic) Hypercalcaemia; metastatic calcification
Side effects
D and analogues (systemic) Common or very common Abdominal pain; headache; hypercalcaemia; hypercalciuria; nausea; skin reactions Uncommon Appetite decreased; arrhythmia; asthenia; constipation; diarrhoea; dry mouth; myalgia; vomiting; weight decreased Overdose Symptoms of overdosage include anorexia, lassitude, nausea and vomiting, diarrhoea, constipation, weight loss, polyuria, sweating, headache, thirst, vertigo, and raised concentrations of calcium and phosphate in plasma and urine. Side-effects For paricalcitol General side-effects: Common or very common Electrolyte imbalance; hypoparathyroidism; taste altered Uncommon Dizziness; malaise; pain Frequency not known Angioedema; laryngeal oedema Specific side-effects: Uncommon With oral use Breast tenderness; gastrointestinal discomfort; gastrooesophageal reflux disease; muscle spasms; palpitations; peripheral oedema; pneumonia With parenteral use Alopecia; anaemia; anxiety; asthma; atrial flutter; breast cancer; breast pain; cardiac arrest; cerebrovascular insufficiency; chest pain; coma; condition aggravated; confusion; conjunctivitis; cough; delirium; depersonalisation; dyspepsia; dysphagia; dyspnoea; ear disorder; erectile dysfunction; fever; gait abnormal; gastrointestinal disorders; glaucoma; haemorrhage; hirsutism; hyperhidrosis; hyperparathyroidism; hypertension; hypotension; increased risk of infection; insomnia; joint disorders; leucopenia; lymphadenopathy; muscle twitching; myoclonus; oedema; pulmonary oedema; sensation abnormal; sepsis; syncope; thirst
Interactions
**Other interactions (9):**
- Ketoconazole Ketoconazole is known to be a nonspecific inhibitor of several cytochrome P450 enzymes.
- The available in vivo and in vitro data suggest that ketoconazole may interact with enzymes that are responsible for the metabolism of paricalcitol and other vitamin D analogs.
- Caution should be taken while dosing paricalcitol with ketoconazole.
- The effect of multiple doses of ketaconazole administered as 200 mg, twice daily (BID) for 5 days on the pharmacokinetics of paricalcitol capsule has been studied in healthy subjects.
- The mean half-life of paricalcitol was 17.0 hours in the presence of ketoconazole as compared to 9.8 hours, when paricalcitol was administered alone (see PRECAUTIONS section 4.4).
- The results of this study indicate that following either oral or intravenous administration of paricalcitol the maximum amplification of the paricalcitol AUCINF from a drug interaction with...
Pregnancy
D and analogues (systemic) High doses teratogenic in animals but therapeutic doses unlikely to be harmful. Pregnancy For paricalcitol Manufacturer advises avoid-toxicity in animal studies.
Breast feeding
D and analogues (systemic) Caution with high doses; may cause hypercalcaemia in infant-monitor serum-calcium concentration. Breast feeding For paricalcitol Manufacturer advises avoid-no information available.
Medicinal forms
Capsule,Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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