Formulary
Pancreatin: Indications, Dosing, Side Effects and Interactions
Supplements of pancreatin are given to compensate for reduced or absent exocrine secretion.
MedNext Academy | 3 min read
Pancreatin: Indications, Dosing, Side Effects and Interactions
Supplements of pancreatin are given to compensate for reduced or absent exocrine secretion.
Drug action
Supplements of pancreatin are given to compensate for reduced or absent exocrine secretion. They assist the digestion of starch, fat, and protein.
Indications and dose
**Pancreatic insufficiency**
- **Child** (By Mouth): 0.5-2 g, to be taken before or with meals, washed down or mixed with milk or water.
- **Adult** (By Mouth): 0.5-2 g, to be taken before or with meals, washed down or mixed with milk or water.
**Pancreatic insufficiency for Creon 10000**
- **Child** (By mouth): Initially 1-2 capsules, dose to be taken with each meal either taken whole or contents mixed with acidic fluid or soft food (then swallowed immediately without chewing).
**Pancreatic insufficiency for Creon 25000**
- **Child 2-17 years** (By mouth): Initially 1-2 capsules, dose to be taken with each meal either taken whole or contents mixed with acidic fluid or soft food (then swallowed immediately without chewing).
**Pancreatic insufficiency for Creon Micro**
- **Neonate** (By mouth): Initially 100 mg, for administration advice, see Directions for administration.
- **Child** (By mouth): Initially 100 mg, for administration advice, see Directions for administration.
**Pancreatic insufficiency for Nutrizym 22 gastro-resistant capsules**
- **Child 15-17 years** (By mouth): Initially 1-2 capsules, dose to be taken with meals and 1 capsule as required, dose to be taken with snacks, doses should be swallowed whole or contents taken with water, or mixed with acidic fluid or soft food (then swallowed immediately without chewing).
**Pancreatic insufficiency for Pancrex V**
- **Child 1-11 months** (By mouth): 1-2 capsules, contents of capsule to be mixed with feeds.
- **Child 1-17 years** (By mouth): 2-6 capsules, dose to be taken with each meal either swallowed whole or sprinkled on food.
**Pancreatic insufficiency for Pancrex V capsules '125'**
- **Neonate** (By mouth): 1-2 capsules, contents of capsule to be given in each feed (or mixed with feed and given by spoon).
**Pancreatic insufficiency for Pancrex V powder**
- **Neonate** (By mouth): 250-500 mg, dose to be taken with each feed.
- **Child** (By mouth): 0.5-2 g, to be taken before or with meals, washed down or mixed with milk or water.
Cautions
Can irritate the perioral skin and buccal mucosa if retained in the mouth; excessive doses can cause perianal irritation
Contraindications
For Nutrizym 22 gastro-resistant capsules Should not be used in children aged 15 years or less with cystic fibrosis
Side effects
Common or very common Abdominal distension; constipation; nausea; vomiting Uncommon Skin reactions Frequency not known Fibrosing colonopathy
Interactions
**Other interactions (1):**
- Intestinal adsorbents (e.g.
Pregnancy
Not known to be harmful.
Medicinal forms
Capsule,Capsule,Granules,Powder
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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