Formulary
Oxycodone with naloxone: Indications, Dosing, Side Effects and Interactions
Oxycodone with naloxone clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Oxycodone with naloxone: Indications, Dosing, Side Effects and Interactions
Oxycodone with naloxone clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Severe pain requiring opioid analgesia in patients not currently treated with opioid analgesics**
- **Adult** (By Mouth): Initially 10/5 mg every 12 hours (max. per dose 40/20 mg every 12 hours), dose to be increased according to response; patients already receiving opioid analgesics can start with a higher dose.
**Second-line treatment of symptomatic severe to very severe idiopathic restless legs syndrome after failure of dopaminergic therapy**
- **Adult** (By Mouth): Initially 5/2.5 mg every 12 hours, adjusted weekly according to response, usual dose 10/5 mg every 12 hours; maximum 60/30 mg per day.
Medicinal forms
Suspension
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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