Formulary
Olmesartan with hydrochlorothiazide: Indications, Dosing, Side Effects and Interactions
Olmesartan with hydrochlorothiazide clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Olmesartan with hydrochlorothiazide: Indications, Dosing, Side Effects and Interactions
Olmesartan with hydrochlorothiazide clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Hypertension not adequately controlled with olmesartan alone**
- **Adult** (By Mouth): (consult product literature).
Interactions
**Severe interactions:**
- Olmesartan medoxomil had no significant effect on the pharmacokinetics or pharmacodynamics of warfarin or the pharmacokinetics of digoxin.
**Other interactions (27):**
- Potential interactions related to both olmesartan medoxomil and hydrochlorothiazide Concomitant use not recommended Lithium Reversible increases in serum lithium concentrations and toxicity have...
- In addition, renal clearance of lithium is reduced by thiazides and consequently the risk of lithium toxicity may be increased.
- Therefore use of olmesartan medoxomil/hydrochlorothiazide and lithium in combination is not recommended (see section 4.4).
- If use of the combination proves necessary, careful monitoring of serum lithium levels is recommended.
- Concomitant use requiring caution Baclofen Potentiation of antihypertensive effect may occur.
- Non-steroidal anti-inflammatory medicinal products NSAIDs (i.e.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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