Formulary
Nepafenac: Indications, Dosing, Side Effects and Interactions
Nepafenac clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Nepafenac: Indications, Dosing, Side Effects and Interactions
Nepafenac clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Prophylaxis and treatment of postoperative pain and inflammation associated with cataract surgery,Reduction in the risk of postoperative macular oedema associated with cataract surgery in diabetic patients**
- **Adult** (To The Eye): (consult product literature).
Cautions
Avoid sunlight; bleeding tendency (increased risk of ocular tissue bleeding, including hyphaema); concomitant use of ocular corticosteroids; corneal epithelial breakdown (if evidence of, then discontinue immediately); may mask symptoms of infection; may slow or delay wound healing; patients at increased risk of corneal side-effects Cautions, further information Concomitant use of ocular corticosteroids Concomitant use of ocular formulations containing NSAIDs with ocular formulations containing corticosteroids may increase the risk of corneal healing problems, leading to corneal melt or scarring and loss of vision. M Patients at increased risk of corneal side-effects Patients with complicated ocular surgeries, corneal denervation, corneal epithelial defects, diabetes mellitus, ocular surface diseases, rheumatoid arthritis, or repeat ocular surgeries within a short period of time may be at increased risk of corneal side-effects which may become sight threatening. M
Side effects
Eye discomfort; eye disorders; eye inflammation Rare or very rare Allergic dermatitis; corneal deposits; dizziness; dry eye; headache; nausea Frequency not known Cutis laxa; vision disorders; vomiting Side-effects, further information Prolonged use can cause epithelial breakdown, corneal thinning, corneal erosion, corneal ulceration and corneal perforation which might be sight-threatening. Discontinue if corneal epithelial breakdown occurs and monitor closely.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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