Formulary
Nefopam hydrochloride: Indications, Dosing, Side Effects and Interactions
Nefopam hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Nefopam hydrochloride: Indications, Dosing, Side Effects and Interactions
Nefopam hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Moderate pain**
- **Adult** (By Mouth): Initially 60 mg 3 times a day, adjusted according to response; usual dose 30-90 mg 3 times a day.
- **Elderly** (By Mouth): Initially 30 mg 3 times a day, adjusted according to response; usual dose 30-90 mg 3 times a day.
Cautions
Angle-closure glaucoma; elderly; urinary retention
Contraindications
Convulsive disorders; not indicated for myocardial infarction
Side effects
Uncommon Coma; drowsiness; headache; hyperhidrosis; insomnia; tachycardia; vision blurred; vomiting Rare or very rare Urine discolouration Frequency not known Abdominal pain; angioedema; confusion; diarrhoea; dizziness; dry mouth; gastrointestinal disorder; hallucination; hypotension; nausea; nervousness; palpitations; paraesthesia; seizure; syncope; tremor; urinary retention
Interactions
**Other interactions (3):**
- Caution should be exercised when nefopam is administered concurrently with tricyclic antidepressants.
- It should be noted that nefopam may interfere with some screening tests for benzodiazepines and opioids.
- These tests for benzodiazepines and opioids may give false positive results for patients taking Nefopam 30 mg tablets.
Pregnancy
No information available-avoid unless no safer treatment.
Hepatic impairment
Manufacturer advises caution.
Renal impairment
Use with caution. M Dose adjustments Reduce daily dose in end-stage renal disease. M
Medicinal forms
Suspension
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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