Formulary
Naltrexone with bupropion: Indications, Dosing, Side Effects and Interactions
Naltrexone with bupropion clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Naltrexone with bupropion: Indications, Dosing, Side Effects and Interactions
Naltrexone with bupropion clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Adjunct in obesity (in conjunction with dietary measures and increased physical activity in individuals with a body mass index (BMI) of 30 kg/m2or more or in individuals with a BMI of 27 kg/m2or more in the presence of one or more weight related co-morbidity)**
- **Adult** (By Mouth): Adjunct in obesity (in conjunction with dietary measures and increased physical activity in individuals with a body mass index (BMI) of 30 kg/m 2 or more or in individuals with a BMI of 27 kg/m 2 or more in the presence of one or more weight related co-morbidity) 18-75 years Initially 1 tablet daily for 7 days, then increased to 1 tablet twice daily for 7 days, then increased to 3 tablets daily in divided doses for 7 days, two tablets to be taken in the morning, and one tablet to be taken in the evening, then maintenance 2 tablets twice daily, review treatment after 16 weeks and then annually.
Cautions
For naltrexone with bupropion History of mania; hypertension
Contraindications
For naltrexone with bupropion Uncontrolled hypertension
Hepatic impairment
For naltrexone with bupropion Manufacturer advises avoid (no information available).
Renal impairment
For naltrexone with bupropion Avoid in end-stage renal disease. M Dose adjustments Max. 1 tablet twice daily in moderate to severe impairment. M
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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