Formulary
Nafarelin: Indications, Dosing, Side Effects and Interactions
Administration of gonadorelin analogues produces an initial phase of stimulation; continued administration is followed by down-regulation of...
MedNext Academy | 3 min read
Nafarelin: Indications, Dosing, Side Effects and Interactions
Administration of gonadorelin analogues produces an initial phase of stimulation; continued administration is followed by down-regulation of...
Drug action
Administration of gonadorelin analogues produces an initial phase of stimulation; continued administration is followed by down-regulation of gonadotrophin-releasing hormone receptors, thereby reducing the release of gonadotrophins (follicle stimulating hormone and luteinising hormone) which in turn leads to inhibition of androgen and oestrogen production.
Cautions
Patients with metabolic bone disease (decrease in bone mineral density can occur)
Contraindications
Undiagnosed vaginal bleeding; use longer than 6 months in the treatment of endometriosis (do not repeat)
Side effects
Common or very common Artificial menopause; breast abnormalities; chest pain; depression; dyspnoea; emotional lability; headaches; hirsutism; hot flush; hypersensitivity; hypertension; hypotension; insomnia; myalgia; oedema; oestrogen deficiency; paraesthesia; rhinitis; seborrhoea; sexual dysfunction; skin reactions; uterine haemorrhage; vulvovaginal dryness; weight changes Uncommon Alopecia; arthralgia; ovarian cyst (may require discontinuation) Frequency not known Ovarian hyperstimulation syndrome; palpitations; vision blurred
Pregnancy
Avoid.
Breast feeding
Avoid.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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