Formulary
Micafungin: Indications, Dosing, Side Effects and Interactions
Micafungin clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Micafungin: Indications, Dosing, Side Effects and Interactions
Micafungin clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Invasive candidiasis**
- **Adult** (By Intravenous Infusion): (body-weight 40 kg and above) 100 mg once daily for at least 14 days; increased if necessary to 200 mg once daily, increase dose if response inadequate.
**Oesophageal candidiasis**
- **Adult** (By Intravenous Infusion): (body-weight 40 kg and above) 150 mg once daily.
**Prophylaxis of candidiasis in patients undergoing bone-marrow transplantation or who are expected to become neutropenic**
- **Adult** (By Intravenous Infusion): (body-weight 40 kg and above) 50 mg once daily continue for at least 7 days after neutrophil count is in desirable range.
**Invasive candidiasis for micafungin**
- **Neonate (administered on expert advice)** (By intravenous infusion): 2 mg/kg once daily for at least 14 days; increased if necessary to 4 mg/kg once daily, increase dose if response inadequate.
- **Child (body-weight up to 40 kg)** (By intravenous infusion): 2 mg/kg once daily for at least 14 days; increased if necessary to 4 mg/kg once daily, increase dose if response inadequate.
- **Child (body-weight 40 kg and above)** (By intravenous infusion): 100 mg once daily for at least 14 days; increased if necessary to 200 mg once daily, increase dose if response inadequate.
**Oesophageal candidiasis for micafungin**
- **Child 16-17 years (body-weight up to 40 kg)** (By intravenous infusion): 3 mg/kg once daily.
- **Child 16-17 years (body-weight 40 kg and above)** (By intravenous infusion): 150 mg once daily.
**Prophylaxis of candidiasis in patients undergoing bone-marrow transplantation or who are expected to become neutropenic for over 10 days for micafungin**
- **Neonate** (By intravenous infusion): 1 mg/kg once daily continue for at least 7 days after neutrophil count is in desirable range.
- **Child (body-weight up to 40 kg)** (By intravenous infusion): 1 mg/kg once daily continue for at least 7 days after neutrophil count is in desirable range.
- **Child (body-weight 40 kg and above)** (By intravenous infusion): 50 mg once daily continue for at least 7 days after neutrophil count is in desirable range.
Side effects
Frequency not known Anaemia; anxiety; appetite decreased; arrhythmias; confusion; constipation; diarrhoea; disseminated intravascular coagulation; dizziness; drowsiness; dyspnoea; electrolyte imbalance; eosinophilia; flushing; gastrointestinal discomfort; haemolysis; haemolytic anaemia; headache; hepatic disorders; hepatic failure (potentially life-threatening); hyperbilirubinaemia; hyperhidrosis; hypersensitivity; hypertension; hypoalbuminaemia; hypotension; insomnia; leucopenia; nausea; neutropenia; palpitations; pancytopenia; peripheral oedema; renal impairment; severe cutaneous adverse reactions (SCARs); shock; skin reactions; taste altered; thrombocytopenia; tremor; vomiting
Interactions
**Other interactions (1):**
- It is unknown whether letermovir may affect the exposure of piperacillin/tazobactam, amphotericine B and micafungin.
Pregnancy
Manufacturer advises avoid unless essential-toxicity in animal studies.
Breast feeding
Manufacturer advises use only if potential benefit outweighs risk-present in milk in animal studies.
Hepatic impairment
Manufacturer advises caution in chronic impairment; avoid in severe impairment (limited information available).
Renal impairment
Use with caution; renal function may deteriorate. M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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