Formulary
Methoxyflurane: Indications, Dosing, Side Effects and Interactions
Methoxyflurane clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Methoxyflurane: Indications, Dosing, Side Effects and Interactions
Methoxyflurane clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Moderate-to-severe pain associated with trauma (under close medical supervision)**
- **Adult** (By Inhalation): 3-6 mL as required, avoid administration on consecutive days; administer using inhaler device; maximum 15 mL per week.
Cautions
Elderly-increased risk of hypotension; repeated administration more than once every 3 months-increased risk of hepatic injury; risk factors for hepatic impairment; risk factors for renal impairment
Contraindications
Cardiovascular disease; history of liver damage associated with use of methoxyflurane or other halogenated anaesthetics; impaired consciousness; respiratory depression; susceptibility to malignant hyperthermia
Side effects
Common or very common Dizziness; drowsiness; dry mouth; headache; nausea Uncommon Anxiety; appetite increased; chills; concentration impaired; cough; depression; fatigue; feeling abnormal; flushing; hyperhidrosis; hypertension; hypotension; memory loss; mood altered; oral disorders; paraesthesia; peripheral neuropathy; speech impairment; taste altered; vision disorders; vomiting Frequency not known Choking; confusion; consciousness impaired; dissociation; hepatic disorders; hypoxia; nephrotoxicity (with high doses); nystagmus; renal failure
Interactions
**Other interactions (9):**
- The metabolism of methoxyflurane is mediated by the CYP 450 enzymes particularly CYP 2E1, CYP 2B6 and to some extent CYP 2A6.
- It is possible that enzyme inducers (such as alcohol or isoniazid for CYP 2E1 and phenobarbital or rifampicin for CYP 2A6 and carbamazepine, efavirenz, rifampicin or nevirapine for CYP 2B6) which...
- Concomitant use of methoxyflurane with medicines (e.g.
- Antibiotics with known nephrotoxic potential include tetracycline, gentamicin, colistin, polymyxin B and amphotericin B.
- It is advisable to avoid using sevoflurane anaesthesia following methoxyflurane analgesia, as sevoflurane increases serum fluoride levels and nephrotoxicity of methoxyflurane is associated with...
- Concomitant use of PENTHROX with CNS depressants, such as opioids, sedatives or hypnotics, general anaesthetics, phenothiazines, tranquillisers, skeletal muscle relaxants, sedating antihistamines...
Pregnancy
Manufacturer advises use with caution-limited information available.
Breast feeding
Manufacturer advises use with caution-limited information available.
Hepatic impairment
Manufacturer advises caution (risk of increased exposure).
Renal impairment
Manufacturer advises avoid.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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