Formulary
Methocarbamol: Indications, Dosing, Side Effects and Interactions
Methocarbamol clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Methocarbamol: Indications, Dosing, Side Effects and Interactions
Methocarbamol clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Short-term symptomatic relief of muscle spasm**
- **Adult** (By Mouth): 1.5 g 4 times a day; reduced to 750 mg 3 times a day if required.
- **Elderly** (By Mouth): Up to 750 mg 4 times a day, dose may be sufficient.
Contraindications
Brain damage; coma; epilepsy; myasthenia gravis; pre-coma
Side effects
Frequency not known Angioedema; anxiety; bradycardia; confusion; conjunctivitis; dizziness; drowsiness; dyspepsia; fever; flushing; headache; hepatic disorders; hypotension; insomnia; leucopenia; memory loss; nasal congestion; nausea; seizures; skin reactions; syncope; taste metallic; vertigo; vision disorders; vomiting
Interactions
**Other interactions (4):**
- When Methocarbamol is used concomitantly with centrally acting medicinal products such as barbiturates, opioids as well as appetite suppressants, an increased interactive effect may occur.
- Consumption of alcohol during treatment with methocarbamol may potentiate the effect.
- The effect of anticholinergics, such as atropine, and other psychotropic medicinal products may be potentiated by methocarbamol.
- Methocarbamol may attenuate the effect of pyridostigmine bromide.
Pregnancy
Manufacturer advises avoid unless potential benefit outweighs risk.
Breast feeding
Present in milk in animal studies - manufacturer advises caution.
Hepatic impairment
Manufacturer advises caution (risk of increased half-life). Dose adjustments Manufacturer advises consider increasing dose interval in chronic impairment.
Renal impairment
Manufacturer advises caution.
Medicinal forms
Suspension
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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