Formulary
Melphalan [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Melphalan [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Melphalan [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Melphalan [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Multiple myeloma**
- **Adult** (By Mouth, Or By Intravenous Injection, Or By Intravenous Infusion): Specialist drug - access specialist resources for dosing information.
**Polycythaemia vera**
- **Adult** (By Mouth): Specialist drug - access specialist resources for dosing information.
Side effects
For melphalan [Specialist drug] General side-effects: Common or very common Alopecia; anaemia; bone marrow depression (delayed); diarrhoea; nausea; stomatitis; thrombocytopenia; vomiting Rare or very rare Haemolytic anaemia; hepatic disorders; interstitial pneumonitis; pulmonary fibrosis; skin reactions Specific side-effects: Common or very common With oral use Leucopenia With parenteral use Feeling hot; myalgia; myopathy; paraesthesia Rare or very rare With parenteral use Peripheral vascular disease Side-effects, further information Secondary malignancy Use of melphalan is associated with an increased incidence of acute leukaemias.
Medicinal forms
Tablet,Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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