Formulary
Maraviroc: Indications, Dosing, Side Effects and Interactions
Maraviroc is an antagonist of the CCR5 chemokine receptor.
MedNext Academy | 3 min read
Maraviroc: Indications, Dosing, Side Effects and Interactions
Maraviroc is an antagonist of the CCR5 chemokine receptor.
Drug action
Maraviroc is an antagonist of the CCR5 chemokine receptor.
Indications and dose
**CCR5-tropic HIV infection in combination with other antiretroviral drugs in patients previously treated with antiretrovirals**
- **Adult** (By Mouth): 300 mg twice daily.
**CCR5-tropic HIV infection in combination with other antiretroviral drugs in patients previously treated with antiretrovirals for maraviroc**
- **Child** (By mouth): (consult local protocol).
Cautions
Cardiovascular disease
Side effects
Common or very common Abdominal pain; anaemia; appetite decreased; asthenia; depression; diarrhoea; flatulence; headache; insomnia; nausea; rash Uncommon Hyperbilirubinaemia; increased risk of infection; myopathy; postural hypotension; proteinuria; renal failure; seizure Rare or very rare Angina pectoris; granulocytopenia; hepatic disorders; metastases; neoplasms; pancytopenia; severe cutaneous adverse reactions (SCARs) Frequency not known Fever; hypersensitivity; immune reconstitution inflammatory syndrome; organ dysfunction; osteonecrosis Side-effects, further information Osteonecrosis Osteonecrosis has been reported in patients with advanced HIV disease or following long-term exposure to combination antiretroviral therapy. Hepatotoxicity Manufacturer advises consider discontinuation if signs or symptoms of acute hepatitis, or increased liver transaminases with systemic symptoms of hypersensitivity occur.
Interactions
**Severe interactions:**
- However, maraviroc does not significantly affect the pharmacokinetics of digoxin in vivo .
- Raltegravir 400 mg BID (maraviroc 300 mg BID) Maraviroc AUC 12 : 0.86 Maraviroc C max : 0.79 Raltegravir AUC 12 : 0.63 Raltegravir C max : 0.67 Raltegravir C 12 : 0.72 No clinically...
- Significant reductions in amprenavir C min observed may result in virological failure in patients NNRTI + PI Efavirenz 600 mg QD + lopinavir/ritonavir 400mg/100 mg BID (maraviroc 300 mg BID)...
**Other interactions (99):**
- Maraviroc is metabolised by cytochrome P450 CYP3A4 and CYP3A5.
- Co-administration of maraviroc with medicinal products that induce CYP3A4 may decrease maraviroc concentrations and reduce its therapeutic effects.
- Co-administration of maraviroc with medicinal products that inhibit CYP3A4 may increase maraviroc plasma concentrations.
- Dose adjustment of maraviroc is recommended when maraviroc is co-administered with potent CYP3A4 inhibitors and/or inducers.
- Maraviroc is a substrate for the transporters P-glycoprotein and OATP1B1, but the effect of these transporters on the exposure to maraviroc is not known.
- Based on the in vitro and clinical data, the potential for maraviroc to affect the pharmacokinetics of co-administered medicinal products is low.
Pregnancy
Manufacturer advises use only if potential benefit outweighs risk-toxicity in animal studies.
Hepatic impairment
Manufacturer advises caution in impairment and in patients with chronic hepatitis (increased risk of hepatic side-effects; limited information available).
Renal impairment
If eGFR less than 80 mL/minute/1.73 m 2 , consult product literature.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Maraviroc in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

